摘要
目的:通过序贯实验法测定不同年龄男性患者罗库溴铵气管插管的半数有效剂量(IED50),并探讨年龄因素对IED50的影响。方法:选择ASAⅠ或Ⅱ级,择期全麻手术男性患者40例,分为中青年组和老年组,每组20例。将气管插管剂量按等比级数分成4个阶梯,中青年组为0.35、0.42、0.5和0.6 mg/kg,老年组为0.31、0.37、0.44和0.53 mg/kg。按照序贯实验方法单次静注罗库溴铵,并计算罗库溴铵气管插管的IED50和95%可信区间(95%CI)。结果:中青年组IED50为0.4502 mg/kg,老年组IED50为0.4039 mg/kg,老年组的IED50是中青年组的89.7%(P<0.05)。老年组血浆总蛋白、白蛋白水平低于中青年组(P<0.05)。结论:序贯试验方法简便高效、结果可信,适用于罗库溴铵气管插管时IED50的测定。中青年男性患者IED50大于老年男性患者,其原因可能与不同年龄患者间血浆蛋白含量等方面的差异有关。
AIM：To determinate the median effective dose（IED50） of rocuronium via tracheal intubation in different ages male patients by sequential experimental method,and study the effect of the age to IED50.METHODS：40 patients（ASA grade Ⅰ or Ⅱ）scheduled for selective surgical procedure under general anaesthesia were studied.The patients were divided into two groups,young men group（n=20） and older men group（n=20）.The tracheal intubation dose was divided into four grades by geometric progression growth,0.35,0.42,0.5,0.6 mg/kg in the young men group and 0.31,0.37,0.44 and 0.53 mg/kg in the older men group.The IED50 and 95% confidence interval（95%CI）of rocuronium during intubation in either group was determined by sequential experimental method.RESULTS：IED50 was 0.4502 mg/kg in the young men group,which was 0.4039 mg/kg in the older men group.The IED50 in the older women group was 89.7% of that in the young women group（P〈0.05）.The concentration of plasma total protein and albumin in the older mengroup was lower than that in the young men group（P〈0.05）.CONCLUSION： Sequential experimential method is a simple,efficient and reliable method for the IED50 determination of rocuronium during intubation.The IED50 was lower in the older men group than that in the young men group,which is possibly related to the difference of the concentration of plasma total protein in different ages male patients.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第9期1040-1043,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
雄甾烷醇类
序贯实验法
半数有效剂量
年龄
androstanols
sequential experimental method
median effective dose
age
