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咽淋巴环非霍奇金淋巴瘤与EB病毒感染的关系 被引量:2

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摘要 目的探讨鼻咽癌高发地区咽淋巴环非霍奇金淋巴瘤(NHL)中EB病毒(EBV)感染的情况及其临床意义。方法选取病理确诊的咽淋巴环NHL30例和同期咽淋巴环非肿瘤性黏膜活检组织10例作为对照组,应用PCR荧光定量技术与原位杂交的方法,分别从DNA及mRNA(EBER1/2)水平检测两组病例中EBV的感染情况。结果(1)30例咽淋巴环NHL(B-NHL18例,T-NHL12例)组织中EBV DNA检出率60%(18/30),EBER1/2阳性率53.3%(16/30),均高于对照组(EBV DNA20%,EBER1/210%),差异有显著性(P<0.05)。(2)B-NHL中EBV DNA检出率77.8%(14/18)高于T-NHL中EBV DNA检出率33.3%(4/12),差异有显著性(P<0.05);而EBER1/2阳性率两者之间差异无显著性(P>0.05)。结论鼻咽癌高发地区,EBV感染与咽淋巴环NHL发生关系密切,且与NHL的分型有关。
出处 《广东医学》 CAS CSCD 北大核心 2009年第11期1669-1671,共3页 Guangdong Medical Journal
基金 江西省卫生厅科技计划项目(编号:053042)
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参考文献10

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