摘要
目的观察灯盏花注射液对老年人体外血栓形成的影响。方法采用YM-200型体外血栓检测仪与XN3-型血黏细胞电泳自动记时仪检测老年冠心病、糖尿病、高血压患者体外血栓形成的特征,通过采用灯盏花注射液进行干预,观察治疗前后血栓形成的变化。结果检测老年冠心病、糖尿病、高血压患者336例,与对照组37例比较,疾病组体外血栓各项指标明显高于对照组(P<0.01);疾病组中选择125例,同时抽血测体外血栓、血液流变学各项指标及血脂,并与对照组比较结果,疾病组各项指标比对照组增高(P<0.01);但疾病组之间各项指标对比差异无统计学意义(P>0.05);选择42例血栓异常患者进行治疗前后对比,灯盏花注射液治疗后血栓长度、血栓湿度及血栓干质量均明显下降(P<0.01)。结论老年冠心病、糖尿病、高血压病患者极易形成血栓或微血栓;灯盏花对血小板黏附聚集和释放功能都有抑制作用,有活血化淤,改善微循环,降低血黏度,增加血流量的作用。
Objective To observe the effects of Breviseapus injection on thrombosis in vitro in the elderly. Methods The characteristics of thrombosis outside the human body in the elderly coronary heart disease, diabetes and high blood pressure patients was detected by YM-200-type detector in vitro together with blood viscosity XN3- cell gel electrophoresis instrument automatically, thrombosis changes intervened by Breviscapus injection were also observed. Results We detected 336 cases and they were coronary heart disease, diabetes and high blood pressure patients, and all blood indexes of disease group were higher than those in 37 cases of control group. We choose 125 cases in disease group and detected their thrombosis, hemorheology and lipid, every index of disease group was higher than the index of control group （P〈0.01）, but between the indexes of disease group, there was no significant difference （P〉0.05）. Forty-two cases of abnormal thrombosis were treated by Breviscapus injection, their thrombosis length and thrombosis humidity and thrombus dry weight in before and after treatment were significantly decreased by Breviscapus injection （P〈0. 01）. Conclusion It was vulnerable to form thrombu and micro-thrombus for the elderly with coronary heart disease, diabetes and high blood pressure. Breviseapus injection can restrain the function of platelet adhesion and release, improve microcirculation, reduce blood viscosity and increase blood flow.
