摘要
目的观察噪声习服对正常清醒豚鼠耳蜗外毛细胞生理特性的影响。方法采用90dB(A)的宽带噪声对20只健康豚鼠进行连续14天的习服暴露,每天暴露8小时。分别于暴露前、暴露14天和暴露停止后7天及暴露停止后14天测试豚鼠DPOAE听力图(DP-gram)及1～8kHz各频率的输入/输出(I/O)函数曲线。结果DP-gram的测试结果显示噪声习服暴露使豚鼠低频段(1～3kHz)DPOAE的幅值升高,其中2及3kHz升高最为明显,分别为5.0及7.5dB(P<0.05);使高频段(4～8kHz)DPOAE幅值出现轻度降低。在I/O曲线的测试结果中,噪声习服暴露使低频(1～3kHz)高强度段(50～70dBSPL)DPOAE的幅值升高,高频段(4～8kHz)幅值轻度下降,在噪声暴露停止后14天又逐渐恢复正常。结论噪声习服暴露可以使豚鼠耳蜗外毛细胞低频段的主动性增强。
Objective To investigate the influence of long-term sound conditioning on the physiology of outer hair cells. Methods Twenty healthy guinea pigs were exposed to a broadband noise for 14 days consecutively at the level 90 dB（A）, 8 h/day. The DP-gram and input/output （I/O） function （1-8 kHz） were measured at preconditioning, fourteen days conditioning, seven days post-conditioning and fourteen days post-conditioning, respectively. Results The results of DP-gram measurements demonstrated that long-term sound conditioning could enhance the DPOAE amplitudes within low frequencies （1-3 kHz, especially 5.0 dB at 2 kHz and 7.5 dB at 3 kHz, P〈0.05） and slightly decrease the DPOAE amplitudes within high frequencies （4-8 kHz）. The results of I/O function test revealed that sound conditioning could enhance the DPOAE amplitudes at high levels （50-70 dB SPL） within low frequencies （1-3 kHz） and decrease the amplitudes within high frequencies （4 - 8 kHz）. Conclusion Sound conditioning can enhance the guinea pigs＇ electromotility of outer hair cells within low frequencies.
出处
《听力学及言语疾病杂志》
CAS
CSCD
北大核心
2009年第5期481-484,共4页
Journal of Audiology and Speech Pathology
关键词
噪声习服
畸变产物耳声发射
外毛细胞
噪声性聋
Sound conditioning
Distortion product otoacoustic emission
Outer hair cells
Noise induced hearing loss
