摘要
肿瘤转移是恶性肿瘤的主要特征,是引起癌症患者死亡的首要因素.肿瘤转移的发生涉及到肿瘤细胞及其所处的微环境中复杂的信号通路,这些信号通路的激活及相互作用介导了肿瘤的转移、侵袭和在血液/淋巴循环系统中存活,以及在转移靶部位的生长过程.肿瘤转移是一个复杂的、多因素调控的动态过程,对于肿瘤转移机制的研究将有助于深入了解转移过程,并可以鉴定到有意义的治疗靶标,为临床诊断和治疗奠定基础.
Tumor metastasis, the main characteristic of malignance tumor, is the primary cause of death for most cancer patients. The initiation of tumor metastasis involves complex signaling pathway within tumor cell and microenvironment, mediating primary tumor metastasis, invasion, survival and arrest in the blood circulation, and progressive growth at the distant site. The most research on the mechanism of tumor metastais will help understand the metastasis process, and identify promising molecular targets for cancer clinical diagnosis and treatment.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2009年第10期1244-1251,共8页
Progress In Biochemistry and Biophysics
基金
国家高技术研究发展计划(863)资助项目(2006AA02A308)~~
