摘要
目的:观察卵巢低反应或储备下降患者体外受精(IVF)过程中进行电针干预对卵细胞质量及妊娠结局的影响。方法:将接受体外受精-胚胎移植(IVF-ET)助孕的60例卵巢低反应或储备下降患者随机分为观察组和对照组,每组30例。两组均给予拮抗剂方案促排卵,观察组加用电针干预,穴取关元、太溪、三阴交等,比较两组疗效。结果:两组患者治疗前各项指标无明显差异。治疗后观察组肾虚症状改善明显,绒毛膜促性腺激素(hCG)注射日血清雌二醇(E2)水平、受精率、卵母细胞成熟率、优质胚胎率、种植率均优于对照组(均P<0.05);观察组卵泡液和血清中干细胞因子(SCF)水平均明显高于对照组(均P<0.05);观察组与对照组相比,临床妊娠率高而流产率低,但组间差异均无统计学意义(均P>0.05)。结论:电针干预对卵巢储备下降的IVF患者有良好的临床效果,可提高卵细胞质量及妊娠结局。
Objective To observe the effect of electroacupuncture therapy on oocyte quality and pregnancy outcome of patients with poor ovarian response or decreased reserve in the course of in vitro fertilization （IVF）. Methods Sixty cases accepting IVF ET were randomly divided into an observation group and a control group, 30 cases in each group. The two groups were both treated with antagonist scheme for ovulation induction, and the eleetroacupuncture intervention was also added in the observation group, Guanyuan （CV 4）, Taixi （KI 3）, Sanyinjiao （SP 6） etc. were selected. The therapeutic effects in the two groups were compared after treatment. Results There was no significant difference between the two groups before treatment. The symptoms of kidney difficiency in the observation group were significantly improved after treatment, and the levels of serum estradiol （E2）, fertilization rate, oocyte maturation rate, good quality embryos rate, and implantation rate in the observation group were superior to those in the control group on human Chorionic Gonadotropin （hCG） injection day （all P〈0.05） ; the levels of stem cell factor （SCF） in follicular fluid and serum in the observation group were significantly higher than those in the control group （both P〈0. 05）. The pregnancy rate in the observation group was higher than that in the control group, and the abortion rate in the observation group was lower than that in the control group, hut there was no significant difference between the two groups （both P〉0.05）. Conclusion Electroacupuncture therapy has a good clinical effect for IVF patients with poor ovarian reserve, and can improve oocyte quality and pregnancy outcome.
出处
《中国针灸》
CAS
CSCD
北大核心
2009年第10期775-779,共5页
Chinese Acupuncture & Moxibustion
基金
山东省自然科学基金项目:Y2007C131
关键词
电针
胚泡移植
卵巢
干细胞因子
Electroacupuncture
Embryo Transfer
Ovary
Stem Cell Factor
