摘要
采用氯胺-T法对神经生长因子（Nervegrowthfactor，NGF）进行碘标记，研究了NGF在小鼠体内的分布与排泄规律。结果表明：NGF在小鼠体内组织器官的分布速率以颈上神经节、甲状腺、胆囊、肾脏、肾上腺等组织较快，各器官的达峰时间为20—30min；肌注125I－NGF72h内，小鼠粪尿中放射性排泄总量达72．55％，其中尿内累积量约占排泄总量的65.64％，而粪便中只占不足7％。
Nerve growth factor(NGF) was iodolabelled with chloramine-T method and its distribution and excretion in mice were investigated. The results showed that the highest levels were found in superior cervical ganglia, thyroid, bile, kidneys and adrenals between 20-30 min after injection, and the peak time in most tissues was also found at 20-30 min. About 72.55% of the injected dose was excreted in stool and urine, among them 65.6% was excreted in urine and only 7.0% in stool within 72h after intramuscular injection.
出处
《核技术》
CAS
CSCD
北大核心
1998年第11期649-652,共4页
Nuclear Techniques
关键词
神经生长因子
排泄
体内分布
碘125
碘标记
Nerve growth factor(NGF), (125)~I labelled, Distribution, Excretion
