摘要
为了解肝胆能（Galle－Donau）中两种主要成分α—NAA和NTMC的药理作用和它对肝胆动力学的影响，将60只小鼠分为3组，分别灌胃α—NAA10mg、NTMC10mg和生理盐水0.2mL，紧接着各自静脉注射99m-Tc-甲溴菲宁（Mebrofenin）370kBq。分别于5、15、30、60min处死后测放射性。α—NAA组30min后、NTMC组5min后表现出胆汁分泌增加，放射量明显增加。提示肝胆能对肝脏动力学影响明显。
The pharmacological action and hepatobilliary dynamics of the two chief components, a NAA and NTMC of Galle-Donau was reported. Sixty mices were divided into 3 groups. In each group 10mg α-NAA, 10mg NTMC and 0.2mL normal saline, was gastrogavared respectively. 370kBq 99mTc-Mebrofenin was injected intravenously in each mouse and they were killed and the organ radioactivity of each mouse was measured after 5, 15, 30 and 60 minutes, respectively. The results showed that 30 minutes in the group of α-NAA and 5 minutes in the group of NTMC,appeared the increased secretion of 99mTc-Mebrofenin, and the radioactivity in binary system was significant increased. It was concluduced that it demonstrated that Galle-Donau has a significant influence on hepatobilliary dynamics.
出处
《核技术》
EI
CAS
CSCD
北大核心
1998年第11期680-682,共3页
Nuclear Techniques
关键词
动力学
放射性药物
动物实验
显像剂
肝胆能
Kinetics, Hepatobiliary radiopharmaceuticals, Animal experiment,(99m)Tc-Mebrofenin
