摘要
目的:探讨HLA-DRB1基因多态性与汉族人群结核病的遗传相关性。方法:用聚合酶链反应-序列多态性分析(PCR-SSP)技术分别对47例贵州地区汉族活动性结核病患者及53例汉族健康对照者进行HLA-DRB1等位基因分型。结果:在等位基因HLA-DRB1中,结核病患者的HLA-DRB1*16的基因频率明显高于正常对照组(P<0.05),而HLA-DRB1*11基因频率则低于正常对照组(P<0.05)。结论:HLA-DRB1*16可能为贵州地区汉族人群结核病的易感基因,HLA-DRB1*11可能为汉族人群结核病的保护基因。
Objective： To determine whether or not the polymorphisms of the HLA-DRB1 gene are associated with tuberculosis heredity in Han people. Methods ： The polymorphisms of the HLA- DRB1 gene were typed by polymerase chain reaction- sequence specific primers （PCR-SSP） technique among 53 healthy controls and 47 tuberculosis cases of Han people from Guizhou province. Results： The frequency of HLA-DRB1 ＊ 16 allele in tuberculosis cases was significant higher than that in healthy controls （P 〈 0.05） , but frequency of HLA-DRB1 ＊ 11 allele was lower than （P 〈 0.05 ）. Conclusion ： The results suggest that HLA-DRB1 ＊ 11 allele is closely correlated to the incidence of tuberculosis in this population of Han nationality, while HLA-DRB1 ＊ 11 allele may be associated with an antagonist effect in the pathogenesis of pulmonary tuberculosis in this population.
出处
《海南医学院学报》
CAS
2009年第11期1343-1345,共3页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020090225)~~
