摘要
目的:探讨磁共振弥散张量成像(diffusion tensor imaging,DTI)对脊髓损伤的临床应用价值。方法:选择42例健康志愿者作为对照组和54例脊髓型颈椎病作为病例组进行颈椎常规磁共振成像(MRI)及DTI,分别测量各组表观弥散系数(apparent diffusion coefficient,ADC)、部分各项异性(fraction-al anisotropy,FA)值,并显示其弥散张量纤维束(diffusion tensor tracking,DTT)。结果:对照组的平均ADC值为(830.34±215.86)×106mm2/s,平均FA值为(536.03±40.00)×10-3。脊髓慢性损伤患者平均ADC值为(1107.60±47.55)×106mm2/s,较对照组升高,有统计学意义(P<0.01),平均FA值为(425.91±59.48)×10-3,较对照组下降,有统计学意义(P<0.01)。结论:DTI较常规MRI成像能更早显示脊髓的损伤,ADC值、FA值及DTT图是检测早期脊髓损伤微观结构的敏感指标。
Objective ： To investigate the clinical application of magnetic resonance （MR） diffusion tensor imaging for spinal cord injury diagnosis. Methods： Conventional cervical magnetic resonance imaging （MRI） scanning and MR diffusion tensor imaging were performed on 54 patients with cervical spondylotic myelopathy and 42 cases of healthy volunteers as a healthy control group. Apparent diffusion coefficient （ADC） and fractional anisotropy （FA） were measured, diffusion tensor tracking （DTT） was showed in each group. Results： The average ADC value is（830.34±215.86） × 10^6 mm^2/s, the average FA value is （536.03 ±40.00）×10^-3in control group; in contrast the average ADC value is（ 1 107.60 ± 47.55 ） × 10^6 mm……2/s, higher than the control group with statistical significant difference（P 〈0.01 ）, and the average FA value is （425.91±59.48） × 10^-3, lower than the control group with statistical significant difference（P 〈0.01 ）. Conclusion： MR diffusion tensor imaging can show the injury in the spinal cord at earlier stage. ADC value, FA value and DTT are sensitive indicators of the early detection of microtructure of spinal cord injury.
出处
《海南医学院学报》
CAS
2009年第11期1427-1430,共4页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020090242)~~
关键词
磁共振
弥散张量成像
脊髓损伤
MR
Diffusion tensor imaging
Spinal cord injury
