摘要
目的探讨中间性肿瘤细胞减灭术在晚期卵巢癌治疗中的价值。方法采用回顾性方法将曾行肿瘤减灭术患者按术前是否化疗分为两组,即初次肿瘤细胞减灭术组和中间性肿瘤细胞减灭术组,比较两组患者的预后有关指标及生存情况。结果1998年1月至2008年12月共收治IIIc-IV期卵巢上皮性肿瘤92例,其中初次肿瘤细胞减灭术组52例,中间性肿瘤细胞减灭术组39例。两组手术范围相同,中间性肿瘤细胞减灭术组期别晚,细胞分化差,预后不良病理类型所占比例高。两组手术满意比例无差别。随访结果,两组5年生存率无差别。结论对术前评价难以行首次肿瘤细胞减灭术的晚期卵巢癌患者,行中间性肿瘤细胞减灭术可提高患者存活时间。
Objective To evaluate interval cytoreductive surgery in the management of advanced epithelial ovarian cancer.Methods The patients who had cytoreductive surgery were divided into two groups according to whether they had received chemotherapy or not before operation.Retrospective analysis was made,while the prognostic factors and survival rates were compared.Results From Jan.1998 to Dec.2008,92 cases of epithelial ovarian cancer in stage IIIc and stage IV were admitted and all of them were treated by cytoreductive surgery in our hospital.Of which,52 cases had primary cytoreductive surgeries,while the other 39 cases had interval cytoreductive surgery with 2-4 courses of chemotherapies before the operations.More patients with stage IV disease,higher cytological grade and poor aggressive histological type were in the group of interval cytoreductive surgery.However the rates of optimal cytoreductive surgery were similar.Five year survival rates of the two groups were similar,respectively（P〉0.8）.Conclusion Patients who can not initially be cytoreduced to an optimal state should be considered candidates for interval cytoreductive surgery,and might have better survivals from advanced ovarian carcinoma.
出处
《中国临床保健杂志》
CAS
2009年第6期566-568,共3页
Chinese Journal of Clinical Healthcare
关键词
卵巢肿瘤
卵巢切除术
抗肿瘤联合化疗方案
Ovarian neoplasms
Ovariectomy
Antineoplastic combined chemotherapy protocols
