摘要
GATA-2是对外胚层和中胚层发育至关重要的转录因子,它属于具有保守锌指结构的GATA转录因子家族。GATA家族包括6个成员:分别命名为GATA-1～GATA-6。最新研究表明,GATA-2不仅存在于胚胎器官,还对成体造血细胞系、神经系统、垂体和泌尿生殖系统中细胞的功能和维持都必不可少。本文旨在通过对GATA-2的功能研究进展进行综述,探讨GATA-2在生殖系统中的作用机制,以期更广泛地了解GATA-2基因在生物发育过程中的作用及对相关基因的调控机制,从而为攻克人类相关疾病提供理论依据。
GATA-2 transcription factor plays a critical role in the development of the ectoderm and mesoderm. It belongs to the GATA family, which contains 2 conserved zinc finger DNA-binding domains and is composed of six members, termed from GATA-1 to GATA-6. GATA-2 is present in embryonic tissues and organs and is also found in hematopoietic lineage cells, the nervous system, pituitary and genitourinary system, and is essential for the maintenance of their function in adults. The present review focuses on the critical roles of GATA-2 during the developmental process in vertebrates and tries to explore the molecular mechanism of its regulation in the reproductive system, so as to provide a theoretical basis for the human diseases related to GATA-2.
出处
《四川动物》
CSCD
北大核心
2009年第6期945-948,共4页
Sichuan Journal of Zoology
基金
863高技术研究发展计划(No.2007AA10Z165)
国家自然科学基金项目(No.30770272)
