摘要
目的探讨骨桥蛋白(OPN)和基质金属蛋白酶9(MMP-9)在上皮性卵巢癌中的表达及其相关性。方法采用免疫组化S-P法检测60例上皮性卵巢癌、20例良性卵巢肿瘤、20例交界性卵巢肿瘤以及10例正常卵巢组织中OPN和MMP-9的表达情况。结果OPN和MMP-9在上皮性卵巢癌中表达(109.86±21.51)明显高于交界性卵巢肿瘤(45.81±8.93)、良性卵巢肿瘤(11.86±3.01)及正常卵巢组织(5.32±2.74)。OPN和MMP-9在上皮性卵巢癌中的表达与组织病理分级、临床分期、淋巴结转移均有关,与组织学分型无关;二者在上皮性卵巢癌中的表达呈正相关(r=0.80,P<0.05)。结论OPN和MMP-9表达升高在上皮性卵巢癌的发生、分化、进展过程中起重要的作用,OPN和MMP-9有可能成为治疗卵巢癌的新靶点。
Objective To study the expression and relationship of osteopontin （ OPN ） and matrix metalloproteinase-9 （ MMP-9 ） in epitheikal ovarian carcinoma. Methods Immunohistochemical staining S-P methods was used to detect the expression of OPN and MMP-9 in the samples of 60 epithelial ovarian carcinoma,20 benign ovarian tumor,20 borderline ovarian tumor and 10 normal ovarian tissue. Results The expression level of OPN and MMP-9 in epithelial ovarian carcinoma（ 109.86±21.51 ） were significantly higher than those in borderline ovarian tumor（45.81 ±8.93）,benign ovarian tumor（ 11.86±3.01 ） and normal ovarian tissue（5.32±2.74）. The expression level of OPN and MMP-9 related to the tumor grading, tumor stage and lymph node metastasis, while had no relationship with histological grading. There was significant positive correlation between OPN and MMP-9 in epithelial ovarian carcinoma （r = 0.80, P 〈 0.05）. Conclusion The increased expression of OPN and MMP-9 may play an important role in the plvcess of carcinogenesis, progression and differentiation of epithelial ovarian carcinoma. OPN and MMP-9 may be a useful targets for treatment of ovarian carcinoma.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2009年第10期775-777,共3页
Journal of China Medical University
基金
辽宁省教育厅科学研究计划项目(208776
05L475)
沈阳市科委科学研究计划项目(1081239)
