摘要
目的：探讨遗传易感性对于病因推断的影响。方法：应用单基因易感性模型，流行病学研究中对家庭聚集性的多种测量方法及环境危险度测量方法。结果：遗传易感性影响人群中疾病致病因素的作用（环境相对危险度）的推断；同时影响病例的同胞和对照的同胞中疾病的家庭聚集性的推断。结论：遗传易感性的存在可能稀释环境危险和家族性危险的测量。
Objective:To explore the effects of genetic susceptibility on causal inference Methods:The model of single gene susceptibility, Multiple methods measuring for family aggregation in epidemiology and the measuring methods of environmental risk were used Results:Genetic susceptibility had effects on inferences of factor in disease etiology in the population at large (environmental relative risk), and the role of the presence of familial aggregation of the disease in siblings of cases vs Siblings of controls Conclusion:The presence of genetic susceptibility can dilute both measures of environmental and familial risks and may lead to erroneous etiologic inferences
出处
《天津医科大学学报》
1998年第3期208-212,共5页
Journal of Tianjin Medical University
关键词
遗传易感性
病因推断
环境因素
Genetic susceptibility
Environmental factors
Etiologic inference
