期刊文献+

溶胶凝胶法制备TiO_2/HA复合生物活性涂层及其体外活性 被引量:4

Hydroxyapatite/Titania Composite Coating Processed by Sol–Gel Method and Its Bioactivity in Vitro
下载PDF
导出
摘要 通过溶胶凝胶法在纯钛基体上制备了羟基磷灰石(HA)/TiO2复合生物活性涂层。HA和TiO2溶胶由前驱体制得,按不同摩尔比直接混合两种溶胶来制备混合溶胶。HA可以提高钛基的生物活性,TiO2可以提高涂层与基体的物理、化学相容性和结合强度。粘结拉伸结果表明,复合涂层与基体结合良好,比纯HA涂层与基体的结合强度提高约47%。复合涂层试样于SBF中浸泡4、7和14d的SEM分析结果表明,复合涂层表面的类骨磷灰石生成量较高。成骨细胞实验结果表明,复合涂层上细胞铺展良好。 Hydroxyapatite/titania composite material was coated onto a titanium (pure Ti) substrate by sol-gel method. The HA (Hydroxyapatite) and TiO2 sol were made from precursor and mixed together. The HA was employed to enhance the bioactivity of the Ti substrate, and the TiO2 was to improve the chemical consistency and the bonding strength between the coating and substrate. The HA/TiO2 composite coating adhered tightly to the Ti substrate. The insertion of TiO2 enhanced chemical affinity and physical consistency between HA and Ti substrate. With the insertion of TiO, the crystallinity of HA had been delayed. The specimens with HA/TiO2 composite coating was soaked into SBF for 4, 7, 14 d, and the composite HA coating surface is completely covered by the apatite layer. The composite HA film coated on the pure titanium substrate display good bone like apatite forming ability in SBF. The bioactivity of the composite HA coatings were tested by in vitro cellular culture.
出处 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2008年第A04期551-554,共4页 Rare Metal Materials and Engineering
基金 西安市863成果转化专项(ZH06002) 国家重点基础研究发展计划(2005CB623904)
关键词 溶胶凝胶法 羟基磷灰石 TiO2 复合涂层 体外活性 sol-gel method hydroxyapatite titania composite coating in vitro activity
  • 相关文献

参考文献16

  • 1Long M, Rack H J. Biomaterials[J], 1998, 19:1621.
  • 2Feng Yingfang, Kang Haofang, Zhang Zhen. Chinese Journal of Rare Metals[J], 2001, 25:349.
  • 3Li Yubao(李玉宝).Biological Medical Materials(生物医学材料)[M].Beijing:Chemical Industry Press,2003.
  • 4Kim H M. J Ceram Soc Jpn[J], 2001, 109 (4): 49.
  • 5Su-Lee, Hae-won Kim, Eun-jun Lee et al. Biomaterials Applications[J], 2006, 20:195.
  • 6Sukenik C N, Balachander N, Culp L A et al. J Biomed Mater Res[J], 1990, 24:1307.
  • 7Li P, Kangasniemi I, De Groot K et al. J Am Ceram Soc[J], 1994,77 (5) :1307.
  • 8R Roop Kumar, M Wang. Materials Letters[J], 2002, 55:133.
  • 9Xu W, Hu W Y, Li M H et al. Trans Nonferrous Met Soc[J], 2006, 16:209.
  • 10Wei Xu, Wangyu Hu, Meiheng Li et al. Materials Letters[J], 2006, 60:1575.

二级参考文献12

  • 1郭连峰,张文光,王成焘.纳米羟基磷灰石的制备及结晶尺寸的控制[J].无机化学学报,2004,20(3):291-296. 被引量:24
  • 2Shunsuke Fujibayashi,Masashi Neo,yun-Min Kim.Osteoinduction of porous bioactive titanium metal[J].Biomaterials,2004,25:443~450.
  • 3Kumar R R, Wang M. Functionally graded bioactive coatings of HA-G-Ti composites and their in vivo studies[J]. Mater Lett, 2002, 55:133 ~ 137.
  • 4Li H, Khor KA, Cheang P. Impact formation and microstructure characterization of thermal sprayed hydroxyapatite/titania composite coatings [J].Biomaterials, 2003, 24: 949~957.
  • 5Ramires P A, Romito A, Cosentino F, Milella E. The influence of hydroxyapatite structure induced by titanium and its dioxide[J]. J Mater Sci Lett,1994, 13: 159~161.
  • 6Tsui Y C, Doyle C, Clyne T W. Plasma sprayed hydroxyapatite coatings on titanium substrates Part 2: optimization of coating properties[J]. Biomaterials,1998, 19:2031 ~ 2043.
  • 7Chem J H, Liu M L. Structure and properties of hydroxyapatite bioactive glass composites plasma sprayed on Ti6Al4V[J]. Jourmal of Materials Science:Materials in Medicine, 1994, (5): 279 ~ 283.
  • 8储成林,朱景川,尹钟大,王世栋.致密羟基磷灰石(HA)生物陶瓷烧结行为和力学性能[J].功能材料,1999,30(6):606-609. 被引量:29
  • 9郑学斌,周霞明,张叶方,丁传贤.等离子喷涂HA/TiO_2复合涂层[J].无机材料学报,1999,14(6):956-962. 被引量:14
  • 10陈琦丽,唐超群,肖循.TiO_2纳米微粒的溶胶-凝胶法制备及XRD分析[J].材料科学与工程,2002,20(2):224-226. 被引量:54

共引文献4

同被引文献47

  • 1杨华斌,庞薇,侯雪玲,伍本德.HA——微孔钛基涂层种植体的复合强度[J].稀有金属材料与工程,1993,22(6):49-52. 被引量:1
  • 2郝玉琳,杨锐.纳米高强Ti-Nb-Zr-Sn合金[J].金属学报,2005,41(11):1183-1189. 被引量:21
  • 3ZHOU L.Innuence of Martensitic Transformation on Mechanical Compatibility of Biomedic al Beta Type Titanium Alloy TLM[J].Materials Science and Engineering A,2006,438:391-394.
  • 4DONG Y,LI X,TlAN L,et ai.Towards Long-lasting Antibacterial Stainless Steel Surfaces l>v Conibiniiig Double Glow Plasma Silvering with Active Screen Plasnui Nitriding[J].Acta Biomaterialia,2011,7(1):447-457.
  • 5MAI L,WANG D,HANG S,et al.Synthesis and Bactericidal Ability of Ag/TiO2 Composite Films Deposited on Titanium Plate[J].A ppl Sn if Sci,2010,257:974-978.
  • 6YU B,LEUNG K,GUO Q,et al.Synthesis of Ag-TiO2 Composite Nano Thin Film for Antimicrobial Application[J].Nanotechnology,2011,22(11):115603.
  • 7FU T,SHEN Y,ALAJMI Z,et al.Sol-Gel Derived Ag-con-taining TiO2 Films on Surface Roughened Biomedical NiTi Alloy[J].Ceramics International,2014,40(8):12423-12429.
  • 8SHI X,NAKAGAWA M,KAWACHI G,et al.Surface Modification of Titanium by Hydrothermal Treatment in Mg-con-taining Solution and Early Osteoblast Responses[J].Journal of Materials Science-Materials in Medicine,2012,23(5):1281-1290.
  • 9AKGUN B,DURUCAN C,MELLOTT N.Effect of Silver Incorporation on Crystallization and Microstructural Properties of Sol-Gel Derived Titania Thin Films on Glass[J].Journal of Sol-Gel Science and Technology,2011,58(1):277-289.
  • 10UENO T,YAMADA M,SUZUKI T,et al.Enhancement of Bone-Titanium Integration Profile with UV-photofunctiona-lized Titanium in a Gap Healing Model[J].Biomaterials,2010,31(7):1546-1557.

引证文献4

二级引证文献66

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部