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Toll样受体与消化系统肿瘤的研究进展 被引量：1

Toll-like receptor and cancer of digestive system
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摘要 消化系统恶性肿瘤是最常见的一类恶性肿瘤，严重威胁人类健康，然而目前对其病因及发病机制尚不明确。Toll样受体（Toll—like receptors，TLRs）是一种跨膜受体，在固有免疫中起着重要作用，新近发现TLRs与炎性介质、自身免疫性疾病、肿瘤等有密切联系。已有研究表明TLRs广泛参与消化系统恶性肿瘤的发生发展、免疫逃逸，并在免疫治疗中发挥作用，对TLRs的深入研究可揭示TLRs在常见消化系统恶性肿瘤发生发展中的作用，并可能寻找到治疗肿瘤的新靶点。本文将对TLRs与常见消化系统恶性肿瘤的关系作一综述。 Cancer of digestive system is one of the most common worldwidely cancers and seriously threats to human health. However its etiology and pathogenesis are still not clear. Toll-like receptor （TLR）, a newly discovered transmembrane receptor, plays an important role in innate immunity. Recent researches suggested that TLRs had extensive relationship with inflammation, autoimmune diseases and cancer. A large number of researches indicated that TLRs not only participated in the occurrence, development and immune escape of cancer, but also acted in immunotherapy in digestive system. Further investigation of TLRs may re- veal the effects of TLRs in the development of malignant tumors of digestive system, moreover may find new therputic target for the treatment of cancers. We reviewed the relationship between TLRs and cancers of digestive system.
作者 乔谦 顾澄宇 蔡兵
机构地区 南京医科大学附属无锡市人民医院肝胆外科
出处 《国际外科学杂志》 2009年第11期769-773,共5页 International Journal of Surgery
关键词 TOLL样受体 消化系统肿瘤 免疫治疗 Toll-like receptor cancer of digestive system immunotherapy
分类号 R735 [医药卫生—肿瘤]
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参考文献31

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同被引文献17

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国际外科学杂志
2009年 第11期

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