摘要
目的:研究血管内皮生长因子C(VEGF-C)蛋白在喉癌和正常组织中的表达情况,探讨其与临床相关因素以及淋巴转移的关系,了解VEGF-C蛋白在喉癌颈淋巴结转移中的作用。方法:采用免疫组化法分别检测65例喉癌癌内组织、癌旁组织和15例正常组织中VEGF-C蛋白的表达,观察并分析其表达与年龄、肿瘤病理分化程度、T分期及颈淋巴结转移等临床病理因素之间的关系。结果:喉癌组织不同部位的VEGF-C蛋白表达明显不同。VEGF-C在癌内、癌旁及正常组织中均有表达,但癌内组织的表达阳性率明显高于癌旁组织和正常组织,其表达与TNM分期及颈淋巴结转移密切相关。结论:VEGF-C在喉癌组织中表达明显上调,并与肿瘤T分期、淋巴结转移等临床生物学行为有关,提示VEGF-C有可能在喉癌的发生和发展中起重要作用。
Objective： To study the expression of vascular endothelial growth factor C （ VEGF - C）, which is known to be capable of inducing cell proliferation of lymphatic endothelium and development of lymphatic vessels, and to study its correlation with cervical lymph node metastasis in human laryngeal carcinomas. Methods：The expression of VEGF- C protein in the cancer,its adjacent tissue, and normal tissue obtained from resected specimens of 65 cases of laryngeal cancer was assessed with an immunohistochemical staining assay followed by light microscopic examination, and its relationship with cervical lymph node metastasis was analyzed. Results：Immunohistochemical staining of VEGF - C was different obviously in different localities of the resected. The expression of VEGF - C protein was observed in all the central portion, peripheral tissue, and normal tissue of the postoperative specimens. The positive rate of intratumoral VEGF - C was significantly higher than that of adjacent and normal tissue. It was also noticed that the positive rate of intratumoral VEGF - C was well correlated with pathological grades, T stages and stages of lymph node metastasis. Conclusion： Over expression of VEGF - C may play important roles in laryngeal tumor genesis and correlated with T stage and regional lymph node metastasis.
出处
《牡丹江医学院学报》
2009年第5期4-7,共4页
Journal of Mudanjiang Medical University
基金
黑龙江省普通高等学校青年学术骨干支持计划项目(No1152G050)
关键词
VEGF-C
喉癌
淋巴转移
vascular endothelial growth factor C
laryngeal carcinoma
lymphatic metastasis
