摘要
髓样细胞表达的激发受体-1(triggering receptors expressed by myeloidcells-1,TREM-1)是新近发现的参与单核细胞作用和炎症反应的分子,是自然杀伤细胞受体家族成员,表达于中性粒细胞、成熟单核细胞及巨噬细胞,能增强由Toll样受体(TLR)-2和-4启动的炎症反应,扩大急、慢炎症反应。细菌或真菌感染患者体液中可检测到可溶性TREM-1(sTREM-1),提示其可作为感染的诊断指标;针对TREM-1的靶标治疗是值得深入探讨的抗炎治疗新方法。本文就炎症相关疾病中TREM-1的研究进展作一综述。
Triggering receptor expressed on myeloid cells-1 （TREM） 1, a recently identified molecule, is involved in monocytic activation and inflammatory responses. TREM-1 is a member of natural killer cell receptor family and is expressed on neutrophils, mature monocytes and macrophages, and it can enhance the inflammatory responses mediated by Toll-like receptor-2 and-4,showing a role of inflammation promotion. Reportedly sTREM-1 was detectable in the body fluids in the presence of bacterial or fungal infection; therefore it might be used as a marker for inflammation. In addition, recombinant sTREM 1 may also be a new method for anti-inflammatory therapy. Recently, it has been found that TREM-1 not only promoted the acute inflammatory responses,but also participated in the development of chronic inflammation. This review summarizes the role of TREM-1 in the inflammation-assoclated dieases.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2009年第10期1206-1209,共4页
Academic Journal of Second Military Medical University
基金
国家自然科学基金面上项目(30772138)~~
关键词
髓样细胞表达的激发受体-1
炎症
肿瘤
诊断
治疗
triggering receptor expressed on myeloid cells-1
inflammation
neoplasms
diagnosis
therapy
