摘要
动脉灌注化疗是治疗恶性肿瘤的一种有效的方法,在选择灌注化疗药物时应考虑以下用药原则。①选择肿瘤敏感型药物。②不同抗癌机制药物相配伍。③选择药物配伍的种类和药物之间的相互作用。④浓度依赖型药物为首选。⑤抗癌药物配伍应注意不良反应。⑥灌注的药物对癌细胞的杀伤作用是以原型起作用的。⑦注意给药的顺序和疗程间隔。⑧注意给药个体化由于患者的机体状况不同、肿瘤的不均一性,个别对待是临床治疗的基本原则之一。⑨注意结合化疗药的药代谢动力学特点。⑩还应熟悉常用药物和常见肿瘤的化疗方案。
The intra-arterial infusion chemotherapy is an effective treatment for malignant tumors. The following ten principles should be taken into account when the choice of infusion medication is to be made. （1） The tumor-sensitive drugs should be selected. （2） Pay attention to the compatibility of medicines. （3） Select the type of drug compatibility and drug interactions. （4） Concentration-dependent drugs are the drugs of first choice. （5） Pay attention to side effects when anti-cancer drug compatibility is considered. （6） The perfusion anti-cancer drugs exert their killing effect on the tumor cells in their prototype. （7） Pay attention to the administration order of the drugs and the intervals of treatment. （8） The medication should be individualized as the physical condition and tumor＇s heterogeneity are different from patient to patient. It is one of the fundamental principles to formulate a specific scheme for every given patient. （9） Make full use of the pharmacokinetics features of the anti-cancer drugs in clinical practice. （10） To be familiar with commonly used drugs and common tumor chemotherapeutic formulae is a matter of cardinal significance. （J Intervent Radiol, 2009, 18： 797-800）
出处
《介入放射学杂志》
CSCD
北大核心
2009年第10期797-800,共4页
Journal of Interventional Radiology
关键词
药物选择
选择原则
灌注化疗
drug selection
selection principle
infusion chemotherapy
