摘要
目的:应用血栓形成的几个关键因子血管性血友病因子(VWF)、凝血酶—抗凝血酶复合物(TAT)、纤维蛋白原(FIB)、D二聚体(D-Dimer)作为观察指标,探索经皮冠状动脉介入治疗(PCI)后凝血强度的特点及其术后动态变化。方法:入选我院择期行PCI手术的低危不稳定性心绞痛患者35例,PCI治疗前抽取基线静脉血,然后于PCI术后1h、4h、24h和48h抽取静脉血。采用酶联免疫吸附(ELISA)检测试剂盒以及免疫比浊法进行检测。结果:血管性血友病因子、凝血酶—抗凝血酶复合物、D二聚体在术后1小时即有升高,术后24小时到达高峰,48小时出现下降趋势。术后24小时凝血酶—抗凝血酶复合物与术前比较差异有统计学意义(P<0.05)。纤维蛋白原于术后呈进行性下降,至术后48小时恢复至接近术前水平。结论:PCI术后血管性血友病因子、凝血酶呈高度聚集与激活。PCI术后高危血栓形成患者,强化抗凝、抗血小板治疗可能需要持续到至少术后48小时。
Objective ：The yon Willebrand factor （VWF）, thrombin ,fibrinogen （FIB） and D-dimer were important factors in the process of thrombosis. We explored the extent of thrombosis and studied the changes of these factors after percutaneous coronary intervention （PCI）. Methods ： A total of 35 patients were enrolled, they were with low risk of unstable angina （UA） who received PCI in our hospital. VWF, thrombin-antithrombin （ TAT）, FIB and D-dimer were examined before PCI and 1 h, 4 h, 24 b and 48 h after PCI. VWF,FIB and D-dimer were analyzed by immunoturbidimetry assay,TAT was measured by ELISA. Results ： After PCI,the levels of VWF,TAT and D-Dimer raised at 1 h,achieved peak level at 24 h and began to fall at 48 h. FIB fall down immediately after PCI,recovered to the base level at 48 h of time. Conclusion-The VWF and thrombin presented high level of aggregation activation after PCI. The patients with high risk of thrombosis should take antiplatelet and anticoagulation therapy for at least 48h after PCI.
出处
《中国循环杂志》
CSCD
北大核心
2009年第5期337-340,共4页
Chinese Circulation Journal
