早期乳腺癌保乳手术与根治术的临床疗效分析被引量：87

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摘要目的探讨保留乳房的乳腺癌根治术治疗早期乳腺癌的疗效。方法对237例早期乳腺癌患者进行回顾性研究,46例行保乳手术,术后均行放、化疗。雌激素受体(ER)、孕激素受体(PR)阳性者加用内分泌治疗。81例行改良根治手术,110例行标准根治术(Halsted手术)。结果保乳术组生存率为93.5%(43/46),局部复发率为6.5%(3/46),腋淋巴结复发率为2.2%(1/46),远处转移率为10.9%(5/46)。改良根治术组生存率为91.4%(74/81),局部复发率为6.2%(5/81),腋淋巴结复发率为2.5%(2/81),远处转移率为12.3%(10/81);标准根治术组生存率为90.9%(100/110),局部复发率为6.4%(7/110),腋淋巴结复发率为2.7%(3/110),远处转移率为11.8%(13/110);改良根治术组和标准根治术组同保乳术组比较差异均无统计学意义(P>0.05)。保乳术组术后3例肺转移,2例骨转移;改良根治术组术后2例肺转移,5例骨转移,2例脑转移,1例肝转移;标准根治术组术后3例肺转移,8例骨转移,1例脑转移,1例肝转移。保乳术组美容效果优良率为93.5%,生存质量明显高于其他两组(P<0.05)。结论早期乳腺癌保乳手术近期疗效满意,严格掌握手术指征、规范的切除和术后放、化疗等综合治疗是保乳手术成功的关键。

作者孔雷杨华丽李炜奉典旭秦建民陈腾韩峰

机构地区上海中医药大学附属普陀医院外科上海中医药大学附属普陀医院超室

出处《上海交通大学学报（医学版）》 CAS CSCD 北大核心 2009年第10期1266-1268,1271,共4页 Journal of Shanghai Jiao tong University:Medical Science

关键词乳腺癌保乳手术放疗化疗美容效果

分类号 R737.9 [医药卫生—肿瘤]

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