依达拉奉治疗急性脑梗死的临床疗效评价被引量：2

Clinical Therapeutic Effect of Edaravone for Acute Cerebral Infarction

导出

摘要目的：探讨急性脑梗死的常规治疗和加用依达拉奉治疗的疗效变化。方法：100例急性脑梗死患者随机分为治疗组和对照组,每组各50例,对照组用常规治疗方法（灯盏花和胞二磷胆碱静滴,口服阿司匹林等治疗）,治疗组在常规治疗基础上加用生理盐水250 mL＋依达拉奉注射液30 mg静脉滴注,每日2次,7-14天为1个疗程,进行疗效评定。治疗前、治疗后14天和21天对患者进行欧洲卒中评分（ESS）、日常生活活动能力（ADL）评定。通过增分率判断疗效,同时记录不良反应。结果：治疗组14天和21天评定ESS的有效率分别为78.0%和84.0%,对照组为52.0%和58.0%;14天和21天评定ADL的有效率治疗组为80.0%和88.0%,对照组为56.0%和66.0%;治疗组无明显不良反应.结论：依达拉奉治疗急性脑梗死安全有效。 Objective：To study the difference of therapeutic effect for Acute Cerebral Infarction（ACI） between conventional and edaravone treatment.Methods：100 cases with ACI were divided randomly into the treatment and the control group,50 cases each.Conventional treatment were adopted in the control group,which included CDP-choline iv.and Aspirin PO.Besides conventional treatment,edaravone injection 30 mg,iv.Bid,7 to 14 days were taken in treatment group.Therapeutic effect was assessed through ESS score and ADL score before, 14 days and 21 days after treatment. Results： After 14 days and 21 days, the treatment group＇s ESS efficiency power was 78.0% and 84.0% ,and ADL efficiency rate was 80.0% and 88.0%. While the control group＇s was 52.0% and 58.0% ,and 56.0% and 58.0% respectively. The treatment group had no obvious side effection. Conclusion： Edaravone is an effective and safe medicine for ACI.

作者杨建明

机构地区四川省自贡市第四人民医院

出处《华西医学》 CAS 2009年第8期1925-1927,共3页 West China Medical Journal

关键词依达拉奉急性脑梗死自由基清除剂 edaravone acute cerebral infarction free radical scavenger

分类号 R743.33 [医药卫生—神经病学与精神病学] R973.2 [医药卫生—药品]

引文网络
相关文献

参考文献6

1刘秀坤,董志.治疗急性脑梗死药依达拉奉应用及其相关机制的研究进展[J].国外医学（药学分册）,2005,32(5):314-317. 被引量：82
2王维治,罗祖明.神经病学[M].第五版.北京:人民卫生出版社.
3NIASCNA DS, KREXWIK TF. WIBLIN RT. etal. Assessing patterns of tPA use in acute strokc[ J]. Suoke, 2002,33:354.
4JAIN KK. Neuoprotection in cerebrovascular disease[J].Expert Opin Investig Drugs, 2000,9: 695.
5杨政,吴玉林.治疗急性脑梗死的新型脑保护药依达拉奉[J].中国新药杂志,2002,11(12):911-913. 被引量：353
6聂虎,魏薇,杨旻,韩宇.依达拉奉对复苏大鼠血清特异性烯醇化酶和S100蛋白的影响[J].四川大学学报（医学版）,2007,38(3):550-551. 被引量：6

二级参考文献34

1Oishi R, Itoh Y, Nishibori M, et al. Effect of MCI-186 on ischemiainduced changes in monoamine metabolism in rat brain[J]. Stroke,1989, 20(11): 1557 - 1564.
2Watanabe T, Yuki S, Egawa M, et al. Protective effects of MCI-186on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions[J]. J Pharmacol Exp Ther, 1994, 268(3):1597 - 1604.
3Yamamoto T, Yuki S, Watanabe T, et al. Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia[J]. Brain Res, 1997, 762(1/2):240 -242.
4Watanabe T, Egawa M. Effects of an antistroke agent MCI-186 on cerebral arachidonate cascade[J]. J Pharmacol Exp Ther , 1994,271(3): 1624 - 1629.
5Yoshida H, Sasaki K, Namiki Y, et al. Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase [ J ]. Atherosclerosis, 2005,179(1) :97 - 102.
6Amemiya S, Kamiya T, Nito C, et al. Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats[J]. Eur J Pharmacol, 2005, 516(2): 125 - 130.
7Takahashi G, Sakurai M, Abe K, et al. MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits[J]. J Thorac Cardiovasc Surg , 2003, 126(5):1464- 1466.
8Takahashi G, Sakurai M, Abe K, et al. MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia[J]. Ann Thorac Surg, 2004, 78(2):602-607.
9Kono H, Asakawa M, Fujii H, et al. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin[J]. J Pharmacol Exp Ther, 2003, 307 (1) :74 - 82.
10Nakamoto N, Tada S, Kameyama K, et al. A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury[ J ]. Free Radic Res, 2003, 37 (8): 849 - 859.