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HAART所致脂肪代谢障碍综合征 被引量:2

Lipodystrophy syndrome induced by HAART
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摘要 艾滋病患者长期使用搞病毒药物可导致身体脂肪异常分布、血脂异常、糖代谢紊乱等,统称为脂肪代谢障碍综合征。这些代谢异常可能彼此联系,并增加了心血管疾病的发病率,因而正确处理这些代谢异常变得日益重要。此文对HIY感染者在HAART后的脂质代谢、形体改变与胰岛素抵抗等问题进行了综述。 Long-term treatment with antiretroviral agents in AIDS may be associated with abnormal fat redistribution, dyslipidemia and impaired glucose metabolism, collectively termed lipodystrophy syndrome. These metabolic abnormalities may be interrelated, and are associated with an accelerated risk of cardiovascular disease. Consequently, addressing these abnormalities has become increasingly important to the management of patients with HIV. In this article, the abnormal fat metabolism, body change and insulin resistance in the AIDS patients induced by HARRT are reviewed.
出处 《国际流行病学传染病学杂志》 CAS 2009年第5期331-333,共3页 International Journal of Epidemiology and Infectious Disease
关键词 抗逆转录病毒治疗 高效 脂肪 血脂异常 胰岛素抵抗 Antiretroviral therapy, highly active Fat Dyslipidemia Insulin resistance
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  • 1Dube M,Fenton M.Lipid abnonnalities.din Infect Dis,2003,36(Suppl 2):S79-S83.
  • 2Lichtenstein KA.Redefining lipodystrophy syndrome.Risks and impact on clinical decision making.J Acquir Immune Defic Syndr,2005,39(4):395-400.
  • 3Gordon DJ,Probstfield JL,Garrison RJ,et al.High-density lipoprotein cholesterol and cardiovascular disease.Four prospective American studies.Circulation,1989,79(1):8-15.
  • 4Grundy SM,Cleeman JI,Merz CN,et al.Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel Ⅲ guidelines.Circulation,2004,110(2):227-239.
  • 5Nordestgaard BG,Benn M,Schnohr P,et al.Nonfasting triglycerides and risk of myocardial infarction,ischemic heart disease,and death in men and women.JAMA,2007,298(3):299-308.
  • 6El-Sadr W,Reiss P,De Wit S,et al.Relationship between prolonged exposure to combination ART and myocardial infarction:effect of sex,age,and lipid changes.Proceedings of the 12th Conference on Retroviruses and Opportunistic Infections,Boston,USA,2005.
  • 7van Leth F,Phanuphak P,Stroes E,et al.Nevirapine and efavirenz elicit different changes in lipid profiles in antiretroviral-therapy-naive patients infected with HIV-1.PLoS Med,2004,1(1):e19.
  • 8Haubrich RH,Riddler S,DiRienzo G,et al.Metabolic outcomes of ACTG 5142:a prospective,randomized,phase Ⅲ trial of NRTI-,PI-,and NNRTI-sparing regimens for initial treatment of HIV-1 infection.Proceedings of the 14th Conference on Retroviruses and Opportunistic Infections,Los Angeles,USA,2007.
  • 9Grinspoon S,Carr A.Cardiovascular risk and body-fat abnormalities in HIV-infected adults.N Engl J Med,2005,352(1):48-62.
  • 10Wohl D,McComsey G,Tebas P,et al.Current concepts in the diagnosis and management of metabolic complications of HIV infection and its therapy.Clin Infect Dis,2006,43(5):645-653.

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