摘要
目的了解肾病综合征患者停用糖皮质激素(glucocorticoid,GC)后的骨质疏松恢复情况。方法应用双能X线骨密度仪(DEXA)检测79例肾病综合征患者停用糖皮质激素1年后腰椎和股骨颈骨密度情况,记录患者的年龄、性别、体重指数、吸烟史、应用糖皮质激素的时间和累积剂量;分析影响骨质变化的因素。结果79例患者中骨密度正常者占61%,骨量减少者占39%。应用糖皮质激素时间越长的患者骨质恢复相对较慢。结论肾病综合征患者停用激素1年后骨密度可以恢复,且应用激素时间短者恢复快。
[ Objective] To investigate the state of bone mineral density （BMD） after stopping glucocorticoid treatment in patients with nephritic syndrome, and analyze the factors influencing the BMD. [Methods] 79 patients with nephritic syndrome after stopping glucocortieoid therapy （one year later） were observed. BMD in the lumbar spine and the femoral neck were measured by dual-energy X-ray absorptiometry （DEXA）. Age, sex, body-mass-index, smoking history, the time and accumulative dose of glucocorticoid were recorded, the factors that influence the BMD were analyzed. [Results] 79 patients were included in this study. Among them, normal BMD and osteopenia were found in 48 （61%） and 31（39%） patients respectively. The speed of removing nomal BMD with receving longer time glucoeorticoid treatment is significant slower compared with receving shorter time glueocorticoid treatment. [ Conclusion] BMD in patients with nephritic syndrome after stopping glueocorficoid therapy （one year later） could be removed, the shorter the patients reeeved glucocorticoid therapy, the faster the BMD reeoved.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2009年第19期2989-2990,2994,共3页
China Journal of Modern Medicine
基金
河北大学附属医院博士基金课题(No:2005011)
关键词
肾病综合征
糖皮质激素
骨密度
恢复
nephritic syndrome
glucocortieoid treatment
bone mineral density
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