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寄生原虫中糖基磷脂酰肌醇的研究进展 被引量:6

Advanced on the study of GPI of Parasitic protozoa
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摘要 糖基磷脂酰肌醇(GPI)锚作为翻译后修饰成分位于真核生物蛋白的C末端,将修饰后蛋白锚定在细胞膜的外侧小叶上。GPI结构复杂且GPI锚定蛋白在结构和功能上也相差甚远,其在许多生物学过程中都是不可缺少的。寄生原虫膜表面具有大量的GPI锚定蛋白以及GPI相关糖蛋白,能通过周期性的改变来逃避宿主的免疫反应。尽管某些GPI蛋白的特征已明确,但GPI锚的生物功能并没有在分子水平上得到解释。本文对GPI的结构、生物合成以及在原虫中的研究进展作了综述。 The glycosylphosphatidylinositol (GPI) anchor is a posttranslational modification positioned at the C-terminus of many eukaryotic proteins that anchors the modified protein in the outer leaflet of the cell membrane. The structure of GPI anchor is complex and GPI-anehored proteins are structurally and functionally diverse and play vital roles in numerous biological processes. A large number of GPI-anchored protein and GPI-associated glycoprotein accumulated on the parasitic protozoan surface membrane that can escape host immune response through cyclical changes. Although several characters of GPI-protein have been identified, the biological functions of GPI anchor have yet to be elucidated at molecular lever. This review summarized the new research progress on the structure, biosynthesis of GPI and focused on the application of GPI in parasitic protozoan.
作者 覃珊珊 汪琦
出处 《中国病原生物学杂志》 CSCD 2009年第10期787-789,796,共4页 Journal of Pathogen Biology
关键词 寄生原虫 糖基磷脂酰肌醇(GPI) 综述 Parasitic protozoa glycosylphosphatidylinositol(gpi) review
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  • 1Ferguson MA, Homans SW,Dwek RA, et al. Glyeosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the memhrane[J]. Sci, 1988,239 : 753-- 759.
  • 2Nosjean O, Briolay A, Roux BM. GPI proteins: sorting, membrane residence and functions[J]. Biochim Biophys Acta, 1997, 1331: 153--186.
  • 3Low M. In GPI anchored membrane proteins and carbohydrates[M]. LandesCompany,Austin,TX. 1999. 1--14.
  • 4Ferguson MAJ, Williams AF. Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures [ J]. Ann Rev Biochem, 1988,57 : 285 -- 320.
  • 5Macrae JI,Acosta-Serrano A,Morrice NA,et al. A. Structural characterization of NETNES, a novel glyeoconjugate in Trypanosoma cruzi epimastigotes[J]. J Biol Che, 2005,280 : 12201 -- 12211.
  • 6McConville MJ, Collidge TA, Ferguson MAJ, et al. The glycoinositol phospholipids of Leishmania mexicana promastigotes. Evidence for the presence of three distinct pathways of glycolipid hiosynthesis[J]. J Biol Chem, 1993,268 : 15595-- 15604.
  • 7Thomas JR, MeConville MJ, Thomas-Oates JE, et al. Refined structure of the lipophosphoglycan of Leishmania donovani[J]. J Biol Chem, 1992,267 : 6829-- 6833.
  • 8Ilg T,Etges R,Overath P,et al. Structure of Leishmania mericana lipophosphoglycan[J]. J Biol Chem, 1992,267:6834--6840.
  • 9McConville MJ,Schnur LF,Jaffe C,et al. Structure of Leishmania lipophosphoglycan:Inter- and intra-specific polymorphism in Old World species[J]. Biochem J, 1995,310: 807--818.
  • 10Homans SW, Mehlert A, Turco SJ. Solution structure of the lipophosphoglycan of Leishmania donovani [J]. Biochemistry, 1992,31:654--661.

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