摘要
用GeXP（基凶表达谱分析）方法，对16例良性嗜铬细胞瘤、14例恶性嗜铬细胞瘤患者的基因表达进行定量分析，发现肽处理相关基因在恶性嗜铬细胞瘤组表达低于良性嗜铬细胞瘤组表达，其中QPCT、HSPA4L、RNF6、RNF128基因表达较低可能提示嗜铬细胞瘤的恶性潜能更大。
By means of GeXP （gene expression profiling）, quantitative analysis was carried out to investigate the gene expression on pheochromocytoma/paraganglioma specimens. 30 samples were collected from 16 patients with benign pheoehromocytoma and 14 with malignant pheoehromocytoma/paraganglioma. Our results suggest that lower expressions of genes encoding peptide processing factors including QPCT, HSPA4L, RNF6 and RNF128 in pheochromocytomas/paragangliomas may point to a malignant diagnosis.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2009年第5期496-497,共2页
Chinese Journal of Endocrinology and Metabolism
基金
上海市科委启明星计划项目（08QA14057）
关键词
嗜铬细胞瘤
鉴别诊断
基因表达谱分析
基因表达
Pheoehromoeytoma
Differential diagnosis
Gene expression profiling
Gene expression
