摘要
The first successful generation of induced pluripotent stem （iPS） cells from somatic cells was accomplished by introducing four genes into the cell, 0Ct3/4, Sox2, Klf4, and c-myc [1]. While a tour-de-force, this approach to iPS cell generation is inefficient, and unlikely to be directly translated into therapeutic use since it involves the use ofretroviruses to introduce these genes into the cell. Subsequent studies have used non-integrating genetic elements,
