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外周血内脂素水平与冠心病的相关性 被引量:6

Clinical Value of Serum Visfatin in Patients with Coronary Artery Disease
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摘要 目的结合血清高敏C反应蛋白,探讨血清内脂素在预测冠心病斑块稳定性及冠状动脉病变程度的价值。方法对入选对象行冠状动脉造影,同步进行心电图、外周血内脂素、高敏C反应蛋白、肌酸激酶同工酶、心肌肌钙蛋白Ⅰ参数检测和常规身体检查后设正常对照组(25例)和冠心病组(78例);再将冠心病组分为稳定型心绞痛组(34例)、不稳定型心绞痛组(20例)和急性心肌梗死组(24例);同时也将78例冠心病病例分为冠状动脉单支病变(24例)与多支病变(54例)。比较组间外周血内脂素、高敏C反应蛋白水平差异,评价两者在冠心病患者中的相关性及其与冠状动脉病变程度的相关性。结果冠心病组血清内脂素、高敏C反应蛋白水平显著高于正常对照组(P<0.05);血清内脂素、高敏C反应蛋白水平急性心肌梗死组显著高于不稳定型心绞痛组(P<0.05),不稳定型心绞痛组显著高于稳定型心绞痛组(P<0.05);血清内脂素与高敏C反应蛋白水平无明显相关性(P>0.05);多支病变组与单支病变组内脂素水平差异无显著性(P>0.05),而多支病变组高敏C反应蛋白显著高于单支病变组(P<0.05)。结论内脂素和高敏C反应蛋白在预测冠心病中有重要价值,它们在冠心病外周血中浓度的升高可以提示冠状动脉粥样斑块的不稳定,但两者无相关性;高敏C反应蛋白在预测冠状动脉病变程度方面有一定作用,但还不能以内脂素作为预测冠状动脉病变程度的指标。 Aim To determine the clinical value of serum visfatin,as well as to investigate the relationship between the serum level of visfatin and the severity of coronary artery disease(CAD) combined with high sensitive C-reative protein(hs-CRP). Methods All the subjects underwent coronary angiography and serum visfatin,creatine kinase MB isoenzyme(CK-MB),cardiac troponin-Ⅰ(cTnⅠ) and hs-CRP were measured in the subjects.According to diagnostic results,all cases were divided into two groups,normal control group(25 cases) and CAD group(78 cases).At the same time,the 78 cases of CAD were divided into three groups,34 cases of stable angina pectoris(SAP),20 cases of unstable angina pectoris(UAP),24 cases of acute myocardial infarction(AMI).Then CAD group were divided into 24 cases of single vessel coronary disease(1 branch) and 54 cases of multivessel coronary disease(≥2 branches or left trunk).The levels and relationship of serum visfatin and hs-CRP among these groups were compared and analyzed. The relationship between the severity of CAD and the two indicators was evaluated. Results The levels of serum visfatin and hs-CRP in the group of CAD were higher than those of normal control group.The levels of serum visfatin and hs-CRP in the UAP group were higher than that in SAP group(P〈0.05),which in the AMI group were higher than that in UAP group(P〈0.05).There was no significant correlation between serum visfatin and hs-CRP levels(P〉0.05).In the 78 cases of CAD,there was no significant difference of serum visfatin levels between multivessel coronary disease group and single-vessel coronary disease group(P〉0.05),but the levels of serum hs-CRP in multivessel coronary disease group were higher than those in single-vessel coronary disease group. Conclusion The increased serum levels of visfatin and hs-CRP in patients with CAD may predict the unstable conditions of plaques.Hs-CRP plays a role in predicting the severity of CAD to some extent.But we should not predict the severity of CAD by the level of serum visfatin.
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2009年第8期692-694,共3页 Chinese Journal of Arteriosclerosis
关键词 冠状动脉疾病 内脂素 高敏C反应蛋白 Coronary Artery Disease Visfatin Highly Sensitive C-Reative Protein
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  • 1张涛,李自成.冠心病易损斑块的研究进展[J].临床心血管病杂志,2004,20(8):509-512. 被引量:18
  • 2董红梅,黄岚,宋耀明,李爱民,晋军,武晓静,赵刚,耿召华,覃军.急性冠状动脉综合征患者血浆氧化型低密度脂蛋白、高敏C反应蛋白与血管内皮损伤的关系[J].中国动脉硬化杂志,2006,14(3):227-229. 被引量:31
  • 3Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: a protein secreted by visceral fat that mimics the effect of insulin [ J ]. Science, 2005, 307 (5708) : 426-430.
  • 4Curat CA, Wegner V, Sengenes C, et al. Macrophages in human visceral adipose tissue : increase accumulation in obesity and a source of resistin and visfatin [J]. Diabetologia, 2006, 49(4): 744-747.
  • 5Dahl TB, Yndestad A, Skjenand M, et al. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization [J]. Circulation, 2007, 115(8) : 972-980.
  • 6Ridker PM. High sensitivity C- reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease [J]. Circulation, 2001, 103 (13): 1 813-818.
  • 7Ridker PM, Cushman M, Stampfer M J, et al. Plasma concentrations of C- reactive protein and risk of developing peripheral vascular disease [ J ]. Circulation, 1998, 97(5) : 425-428.
  • 8赵庆霞,李海涛,刁增利.冠心病患者不同类型血清氧化型低密度脂蛋白和高敏C反应蛋白水平的差异[J].中国动脉硬化杂志,2008,16(7):559-561. 被引量:4
  • 9Kndish S, Klein J, Lossner U, et al. Hormonal regulation of the novel adipocytokine visfatin in 3T3-LI adipocytes [J]. J Endocrinol, 2005, 185 : R1 -R8.
  • 10张利华,赵季红,薛玉生,刘峰.C反应蛋白与冠心病病变程度相关的研究[J].心脏杂志,2002,14(1):25-26. 被引量:35

二级参考文献54

  • 1王云龙,卢恕来,曾武威,陈保生.高密度脂蛋白抗炎症到促炎症的转变[J].中国动脉硬化杂志,2007,15(3):239-240. 被引量:8
  • 2孙屏,范乐明.高密度脂蛋白的代谢相关基因表达产物与动脉粥样硬化[J].中国动脉硬化杂志,2006,14(6):543-546. 被引量:8
  • 3杨映波 王正国 等.一种分离循环内皮细胞的新方法[J].中国药理学与毒理学杂志,1994,8(1):29-29.
  • 4[1]Braunwald E, Califf RM, Cannon CP, et al. Redefining medical treatment in the management of unstable Angina[J]. Am J Med, 2000,108:41.
  • 5[2]Yamashito K, Ouchi K, Shirai M, et al. Distribution of chlamydia pneumonia infection in the atherosclerotic carotic artery[J]. Stroke, 1998,29:773.
  • 6[3]Mehta JL, Saldeen TG, Rand K. Interaction role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease[J]. J Am Coll Cardiol, 1998,31:1217.
  • 7[4]Jerffery L, Anderson MD, Facc JF, et al. Evaluation of C-reactive protein, an inflammatory marker and infectious serology as risk factors for coronary disease and myocardial infaction[J]. J Am Coll Cardiol, 1998,32:35.
  • 8[5]Tataru MC, Heinrich J, Junker R, et al. C-reactive protein and the severity of atherosclerosis in myocardial infarction patients with stable angina pectoris[J]. Eur Heart J, 2000,21:1000.
  • 9[6]Oltrona L, Ardissino D,Merlini PA, et al. C-reactive protein elevation and early outcome in patients with unstable angina pectoris[J]. Am J Cardiol, 1997,80:1002.
  • 10Zahi A, Fayad Z A, Fuster V, et al. Computed tomography and magnetic resonance imaging for noninvasivc coronary angiography and plaque imaging: current and potential future concepts. Circulation, 2002, 106:2026-2034.

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