摘要
目的:探讨CD44v6及laminin在食管癌组织中的表达及其与食管癌细胞浸润与转移的关系.方法:采用免疫组化方法检测正常食管黏膜组织、良性病变和食管癌组织及癌旁组织中CD44v6和laminin的表达水平.结果:CD44v6在正常食管组织、良性病变及食管癌中的表达依次增高,laminin的表达依次减低(P<0.05);癌旁组织中CD44v6及laminin的表达与正常食管粘膜组织相比,存在统计学差异;食管癌组织中CD44v6及laminin的表达与组织学分级及淋巴结转移有关(P<0.05),而与临床分期无关;另外,CD44v6的表达与生存期也存在一定关系,CD44v6及laminin之间无明显相关关系.结论:CD44v6和laminin在食管癌的恶性转化和侵袭转移过程中可能起重要作用.
AIM：To investigate the expression of CD44v6 and laminin in esophageal carcinoma tissues and the relationship between the expression of CD44v6,laminin and the tumor invasion and metastasis. METHODS：CD44v6 and laminin expression was detected in normal esophageal mucosa,benign lesions,paracancerous tissues and primary tumor tissues with SP immunohistochemistal method. RESULTS：Compared with the normal esophageal mucosa,the expression of CD44v6 and laminin was significantly different in primary tumor tissues and benign lesions （ P 〈 0.05 ）. The expression of CD44v6 and laminin in tissues of normal esophageal mucosa was significantly different from that in paracancer. CD44v6 and laminin expression was closely correlated with the tumor grade and lymphatic metastasis in esophageal carcinoma （ P 〈 0. 05 ）. The presence of CD44v6 and laminin expression has no relation to the clinical stage of the disease. There was no correlation between the expressions of CD44v6 and laminin （P 〉0. 10）. CONCLUSION： The expression of CD44v6 and laminin maybe play an important role in the malignant transformation, invasion and metastasis of esophageal carcinoma.
出处
《第四军医大学学报》
CAS
北大核心
2009年第21期2393-2396,共4页
Journal of the Fourth Military Medical University
