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CK20检测散发性结直肠癌淋巴结微转移的临床意义 被引量:3

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摘要 目的探讨通过细胞角蛋白(CK)20检测散发性结直肠癌淋巴结微转移的临床意义。方法应用RT—PCR方法检测60例结直肠癌根治术所清扫的782枚淋巴结组织中CK20mRNA的表达.从而对淋巴结微转移进行评估.并与常规病理的淋巴结转移情况进行比较。结果常规病理学检出34例(56.7%)患者有淋巴结转移,检出阳性淋巴结数为356枚(45.5%);CK20法检出45例(75.0%)患者有淋巴结转移.阳性淋巴结总数为436枚(55.8%);两组比较,差异具有统计学意义(χ^2=16.72,P〈0.05)。结论CK20法能提高散发性结直肠癌转移淋巴结的检出率.有助于术后临床精准分期。
出处 《中华胃肠外科杂志》 CAS 北大核心 2009年第6期636-637,共2页 Chinese Journal of Gastrointestinal Surgery
基金 山东省烟台市科技发展计划资助项目(2006131-11)
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  • 1Clarke G, Ryan E, O' Keane JC, et al. The detection of cytokeratins in lymph nodes of Duke's B colorectal cancer subjects predicts a poor outcome. Eur J Gastroenterol Hepatol,2000,12(5):549-552.
  • 2Guinebretiere JM, Contesso G. "Micrometastases" : the pathologist's point of view. Bull cancer, 2001,88 (6):549- 550,555-560.
  • 3Bilchik AJ, Saha S, Wiese D, et al. Molecular staging of early colon cancer on the basis of sentinel node analysis:a muhicenter phase II trial. J Clin Oncol, 2001,19 (4): 1128- 1136.
  • 4Merrie AE, van Rij AM, Dennett ER, et al. Prognostic significance of occult metastasis in colon cancer. Dis Colon Rectum, 2003,46(2) : 221-231.
  • 5Okada Y, Fujiwara Y, Yamamoto H, et al. Genetic detection of lymph node micrometastases in patients with gastric carcinoma by multiple marker reverse transcriptase-polymerase chain reaction assay. Cancer, 2001,92 ( 8 ) : 2056-2064.
  • 6Kronberg U, Lopez-Kostner F, Soto G, et al. Detection of lymphatic micrometastases in patients with stages I and II colorectal cancer : impact on five-year survival. Dis Colon Rectum, 2004,47(7) : 1151-1157.

同被引文献27

  • 1Aikaterini Tsouma,Chrysanthi Aggeli,Panagiotis Lembessis,George N Zografos,Dimitris P Korkolis,Dimitrios Pectasides,Maria Skondra,Nikolaos Pissimissis,Anastasia Tzonou,Michael Koutsilieris.Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients[J].World Journal of Gastroenterology,2010,16(47):5965-5974. 被引量:19
  • 2吴泽宇,詹文华,李靖华,何裕隆,汪建平,蔡世荣.胃癌淋巴结微转移与E-钙黏附素表达的关系[J].中华实验外科杂志,2005,22(1):60-62. 被引量:10
  • 3刘津,蔡建辉,阎庆辉,王凤安,宋伟庆,周保军,池口正英.早期胃癌组织中上皮钙粘蛋白表达与淋巴结微转移及临床病理的关系[J].癌症,2007,26(5):541-546. 被引量:4
  • 4Lotspeich E,Schoene M,Gerngross H,et al.Detection of disseminated tumor cells in the lymph nodes of colorectal cancer patients using a real-time polymerase chain reaction assay.Langenbecks Arch Surg,2007,392(5):559-566.
  • 5Hirohashi S,Kanai Y.Cell adhesion system and human cancer morphogenesis.Cancer Sci,2003,94(7):575-581.
  • 6马杰(综述),岳欣(综述),郝希山(审校).恶性肿瘤的微转移和细胞角蛋白检测的应用意义[J].中国综合临床,2008(1):93-94. 被引量:2
  • 7Hirabayashi Y, Yamaguchi K, Shiraishi N, et al. Development of port-site metastasis after pneumoperitoneum [ J ]. Surg Endosc, 2002,16 (5) : 864-868.
  • 8Kilima F, Nateugoe S, Takao S, et al. Detection and clinical sig- nificance Of lymph mode micrometastasis detemined by reverse transcription polymerase chain reacion in patients with esophageal carcinoma[ J]. Oncology ,2000,58 ( 1 ) :38-44.
  • 9Min m M, Ich Kawa Y, Tanaka K, et al. Real-time PCR( Taq Man PCR) quantification of carcinom bryonic antigen(CEA) mRNA in the Peripherel blood of colometal cancer patients [ J ]. Anticancer Res ,2003,23 (25) : 1271-1275.
  • 10Montezuma D, Azevedo R, Lopes P, et al. Apanel of four fmmuno histochemical markes ( CK7, CK20, TTF-1, and p63 ) allows accurate diagnosis of primary and metastatic lung carcinoma on bio- sy specimens [ J ]. Virchows Arch,2013,453 (6) :749-754.

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