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间充质干细胞与肿瘤:抑制或促进? 被引量：6

Mesenchymal stem cells and tumors:inhibition or promotion?
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摘要 间充质干细胞(mesenchymal stem cells,MSCs)是存在于骨髓等组织中的一种具有高度自我更新能力和多向分化潜能的非造血干细胞,具有对创伤及肿瘤组织较为特异的趋向性。MSCs与肿瘤微环境之间存在复杂的交互作用。一方面,MSCs可直接作用于肿瘤细胞抑制其生长;也可作为抗原提呈细胞,激活肿瘤抗原特异性免疫应答;还可作为细胞载体,传递和表达多种抗肿瘤治疗因子,参与抗肿瘤药物的运输、免疫应答的激活以及新生血管的抑制。另一方面,MSCs强大的分化和增殖能力促使其参与肿瘤组织的构建;通过多种趋化因子作用引起肿瘤细胞表型变化,促进肿瘤恶性行为;MSCs具有类似"免疫豁免"效应,可对各主要类型的免疫细胞产生增殖和活化抑制作用,有助于肿瘤细胞逃逸;表达于MSCs表面的多种生长因子和细胞因子可协同促进肿瘤血管和淋巴管生成,参与肿瘤侵袭、转移。MSCs尚具有恶变潜能,在某些条件下可自发转化为致瘤干细胞。
作者 封冰 陈龙邦
机构地区 南京大学医学院临床学院 南京军区南京总医院肿瘤内科
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2009年第5期532-536,545,共6页 Chinese Journal of Cancer Biotherapy
基金 国家自然科学基金项目(No.30872979)~~
关键词 间充质干细胞 载体 肿瘤微环境
分类号 R730.2 [医药卫生—肿瘤] Q279 [生物学—细胞生物学]
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参考文献48

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二级参考文献22

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共引文献6

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中国肿瘤生物治疗杂志
2009年 第5期

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