摘要
目的:了解银离子敷料联合水凝胶促进Ⅱ度烧伤创面愈合的作用。方法:选择2007-05/2009-05南通市第一人民医院烧伤整形科住院烧伤患者104例作为观察对象。随机分为2组:治疗组应用银离子敷料联合水凝胶序贯换药;对照组采用1%磺胺嘧啶银冷霜抹在凡士林纱布上外敷,于伤后7,10,15,17,21d进行创面分泌物细菌培养、观察记录创面愈合情况及速度、观察药物不良反应、换药时创面痛感、肉芽破坏情况。结果:治疗组创面细菌检出率明显低于对照组(P<0.05)。治疗组浅Ⅱ度创面愈合时间比对照组平均缩短三四天,治疗组深Ⅱ度创面愈合时间比对照组平均缩短五六天。治疗组创面愈合速度较对照组明显加快(P<0.05)。两组均无药物不良反应,治疗组创面换药时无明显疼痛感,肉芽组织无明显破坏。结论:银离子敷料联合水凝胶序贯治疗Ⅱ度烧伤创面具有显著抗菌及促进创面肉芽组织和上皮再生、促进创面愈合的作用,且无不良反应。
OBJECTIVE： To understand the efficacy of ionic silver dressing combined with hydrogel on promoting degree Ⅱ burn wound healing. METHODS： A total of 104 patients were selected from the Department of Burn and Plastic Surgery, First People’s Hospital of Nantong from May 2007 to May 2009. All cases were randomly divided into treatment group （ionic silver dressing combined with hydrogel were used） and control group （1% silver sulfadiazine was used）. Secretions extracted from wound were performed with bacterial culture at days 7, 10, 15, 17 and 21 after burning to record healing condition and velocity and observe adverse reaction, wound painfulness, and granulation damage. RESULTS： The detection rate of wound bacteria in the treatment group was significantly lower than control group （P 〈 0.05）. Wound healing time of the superficial degree Ⅱ in the treatment group was shorted 3.0-4.0 days compared with control group, and wound healing time of deep degree Ⅱ was shorted 5.0-6.0 days. The speed of wound healing in the treatment group was significantly faster than control group （P 〈 0.05）. There were no adverse reactions in both groups; additionally, the treatment group had no significant pain and no significant damage to granulation tissue during wound dressing. CONCLUSION： The ionic silver dressing combined with hydrogel remarkably promotes regeneration of granulation tissue and epithelial cells and accelerates wound healing; in addition, the combination has no adverse effect on the degree Ⅱ burn wound.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第42期8373-8376,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
