6Liu B, Neufeld AH. Activation of epidermal groth factor receptors in astrocytes:from development to neural injury[J]. J Neurosci Res, 2007,85:3523-3529.
7McCarthy KD, Vellis JD. Preparation of separate astroglial and oligdendroglial cell cultures from rat cerebral tissue[ J]. J Cell Biol, 1980,85 : 890-902.
9Zhang M, Wang A, Xia T, et al. Effects of fluoride on DNA damage, S-phase cell-cycle arrest and the expression of NF-kappaB in primary cultured rat hippocampal neurons [ J]. Toxicol Lett, 2008,197 : 1-5.
4Mates JM. Effect of antioxidant enzymes in the molecular control of reactive oxygen species toxicology [J]. Toxicology, 2000,153:83-104.
5Chlubek D. Fluoride and oxidative stress[J]. Fluoride, 2003, 36: 1-12.
6Gaspary WJ, Myhr B, Bowers L, et al. Mutagenic activity of fluoride in mouse lymphoma cells[J]. Mutat Res, 1987,187: 165-167.
7Refsnes M, Schwarze PE, Holme JA, et al. Fluoride-induced apoptosis in human epithelial lung cells (A549 cells): role of different G protein-linked signal systems [J]. Hum Exp Toxicol,2003,22(3) : 111-123.
8Anuradha CD, Kanno S, Hirano S. Oxidative damage to mitochondia is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL60 cells[J]. Free Radic Biol Med, 2001,31 (3):367-373.
9Wang AG, Chu QL, He WH, et al. Effects on protein and mRNA expression level of p53 induced by fluoride in human embryonic hepatocytes[J]. Toxicol Lett, 2005,158(2) : 158-163.
10Kaufmann JA, Bickford PC, Taglialatela G. Free radical-dependent changes in constitutive nuclear factor kappa bin the aged hippocampus[J ]. Neuroreport, 2002,13( 15 ) : 1917-1928.
3ABBOTT N J, PATABENDIGE A A, DOLMAN D E, et al. Structure and function of the blood-brain barrier [ J ]. Neurobiol Dis, 2009,37 (1) :13 -25.
4AGARWAL S, ROY S, RAY A, et al. Arsenic trioxide and lead acetate induce apoptosis in adult rat hepatic stem cells[J]. Cell Biol Toxicol, 2009,25(4) :403 -413.
5HE L,POBLENZ A T, MEDRANO C I,et al. Lead and calcium produce rod photoreceptor cell apeptosis by opening the mitochondrial permeability transition pore[ J ]. J Biol Chem, 2000,275 ( 16 ) : 12175 - 12184.
6CRYNS V, YUAN J. Proteases to die for[ J]. Genes Dev, 1998,12 (11) :1551 -1570.
7COMMUNAL C ,SUMANDEA M ,DE TOMBE P,et al. Functional consequences of caspase activation in cardiac myocytcs [ J ]. Proc Nail Acad Sci USA ,2002,99 (9) :6252 - 6256.
8XU J,JI L D, XU L H. Lead-induced apoptosis in PC 12 cells:involvement of p53, Bcl-2 family and caspase-3 [ J]. Toxicol Lett,2006,166 (2) :160 - 167.
9ENARI M, SAKAHIRA H, YOKOYAMA H, et al. A caspase-aetivated DNase that degrades DNA during apoptosis, and its inhibitor ICAD [J]. Nature, 1998,391 (6662) :43 -50.
10RAMPINO N, YAMAMOTO H, IONOV Y, et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype[ J]. Science, 1997,275 (5302) :967 - 969.