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药物透过血脑屏障靶向传递系统的研究 被引量：6

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摘要 脑组织受血脑屏障(BBB)的保护阻止了某些有害物质的侵入,但同时也限制了药物的组织摄取而无法实现药物的疗效。本文概括了目前已被证实的可提高跨BBB药物递送途径即:化学传递、生物学传递、短暂性开放血脑屏障、"特洛伊木马"分子运载、纳米技术的应用等方法。系统地综述了有关药物透过血脑屏障靶向传递的思路和研究方法。
作者 全毅 赵春植 韩东汉 高钟镐
机构地区 中国医学科学院中国协和医科大学药物研究所 延边大学医学部临床医学院神经外科
出处 《国际神经病学神经外科学杂志》 2009年第5期466-473,共8页 Journal of International Neurology and Neurosurgery
基金 国家自然科学基金(30873468)
关键词 血脑屏障 靶向传递 “特洛伊木马”分子 纳米材料 药物传递系统
分类号 R96 [医药卫生—药理学]
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参考文献74

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二级参考文献109

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共引文献49

同被引文献111

引证文献6

二级引证文献24

国际神经病学神经外科学杂志
2009年 第5期

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