摘要
目的:探讨CyclinD1和CDK4在新疆维吾尔族妇女宫颈癌发生、发展中的作用及相互关系。方法:采用免疫组化方法,检测100例宫颈癌组织和50例正常宫颈组织中CyclinD1和CDK4蛋白的表达情况。结果:宫颈癌组织中CyclinD1蛋白阳性表达率为75%,高于正常对照组的30%(P<0.01);CDK4蛋白阳性表达率(87%),高于正常对照组(44%)(P<0.01)。结论:CyclinD1和CDK4在新疆维吾尔族妇女宫颈癌中高表达,且与新疆维吾尔族妇女宫颈癌的发生、发展有关。
Objective ：To study the interaction between Cyclin D1 and CDK 4 protein in cervical carcinoma of Uigur women in Xinjiang. Methods ： Cyclin D1 and CDK 4 proteins were detected by using immunohistoehemistry in 100 cases of cervical carcinoma and 50 cases of normal cervica. Rsults：The expression of Cyclin DI and CDK 4 protein were significantly higher in cervical carcinoma than that in normal controls （P 〈 0.01 ）. Conclusion： Over expression of the Cyclin D1 and CDK 4 protein promotes the development of cervical carcinoma of Uigur women in Xin- jiang.
出处
《现代肿瘤医学》
CAS
2009年第11期2198-2200,共3页
Journal of Modern Oncology
基金
国家自然科学基金资助项目(30260036)
石河子大学高层次人才科研启动项目(RCZX200670)
