摘要
研发安全有效的疟疾疫苗是当前全球疟疾防治的重要需求。以生物技术为代表的新型技术的应用,有效推动了疟疾疫苗的研发进程。30多年疟疾疫苗研发已取得了重要的成果,鉴定了一批有价值的疫苗候选抗原,其中一些已进入临床试验,一些结果令人鼓舞。我国疟疾疫苗研发同样取得可喜进展。自主研制PfCP-2.9疟疾疫苗在国内率先进入临床试验,一些疟疾疫苗候选抗原也陆续进入临床前研究阶段。近年来,多种国家科技计划和国际上研究经费的投入也促进我国疟疾疫苗的研发工作。尽管研发有效疫苗以控制乃至根除疟疾是个长期目标,取得疟疾疫苗突破仍需在疟疾免疫学以及多个技术层面上解决一些关键问题,但我们正在朝着这个目标迈进。
It remains an urgent need to develop effective malaria vaccine for global control of malaria. Application of high technologies such as biotechnology has facilitated the process of vaccine development for malaria. In the past 30 years, a large number of vaccine candidate antigens for malaria have been identified and some of them are currently in clinical trials. Major progress in malaria vaccine development has also been made in China. The PfCP-2.9 blood stage vaccine for malaria has entered clinical studies and some other vaccine candidates including combination malaria vaccine are currently in pre-clinical studies. The availability of various national research programs and international funding has stimulated laboratory and pre-clinical studies of malaria vaccine candidates. It remains a long-term goal to develop a safe and effective malaria vaccine to control and even eliminate the disease in the world, and many issues including malaria immunology and various types of technologies need to be addressed. However, efforts need to be continued toward the goal.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2009年第5期390-393,共4页
Chinese Journal of Parasitology and Parasitic Diseases
关键词
疟疾
疫苗
研究
进展
Malaria
Vaccine
Research
Development
