摘要
目的:探讨尿道狭窄患者围手术期尿液TGF-β_1浓度变化情况以及影响该浓度的相关因素。方法:使用ELISA试剂盒对29例尿道狭窄患者术前1个月及术后1个月尿液中TGF-β_1进行测定及记录。同期取泌尿系统其他手术的14例患者作为对照组,测定其术后1个月尿液中TGF-β_1浓度。结果:检测结果显示实验组在接受手术治疗后尿液中TGF-β_1含量较对照组有显著增高(P<0.05)。同时实验组患者术前和术后尿液TGF-β_1浓度也存在明显差异(P<0.05)。在相关性因素的分析中,前尿道狭窄患者术后尿液中TGF-β_1含量的变化幅度较后尿道狭窄患者更为显著(P<0.05),同时采用自体组织替代技术较传统端端吻合技术以及内镜切开技术更能引起尿液中TGF-β_1的明显变化(P<0.05),但年龄、既往手术次数均未能引起患者术后TGF-β_1的变化。结论:狭窄部位、手术方式都与患者尿液中TGF-β_1的含量存在一定的联系,而年龄及既往手术史等因素未发现与患者体内TGF-β_1含量有较大的联系。
Objective：To investigate the changes of concentration of TGF -β1 in the urine of patients with ure thral strictures during the peroperative period and find the correlative factors infecting the concentration potential ly. Methods：The urine concentration of TGF-β1 was detected in 29 patients with urethral strictures using the kit of ELISA. The data of one month before and after the surgery were recorded. Meanwhile, other 14 patients, accept ed other urological procedures, were set as control group and the urine concentration of TGF -β1, from them within one month was detected after the surgery. Results： The results show that the concentration of TGF-β1 in urine was increased significantly in experimental group than in control group, after the surgery （P〈0.05）. Meanwhile, the concentration of TGF-β1 in urine in the patients of experimental group was significantly different before and after the surgery （P〈0.05）. In the analysis of correlative factors, the varying range of concentration of TGF β1 was significant in the urine of anterior urethral stricture patients than in that of posterior ones （P〈0.05）. Compared with end to end anastomosis or direct vision internal urethrotomy （DVIU） procedures, graft substitution method can make significant variation of growth factor in urine（P〈0.05）. Age, history of operation and suprapubic cystostomy do not lead to the significant variation of concentration of TGF -β1 in the urine of patients after the surger y. Conclusions：The results of this study indicated that both the position of urethral stricture and the pattern of sur gery are related to the concentration of TGF-β1 in the urine of patients; however, age, operative history and supra pubic cystostomy are not significantly related to the concentration of TGF -β1 in the urine of patients.
出处
《临床泌尿外科杂志》
北大核心
2009年第11期866-868,872,共4页
Journal of Clinical Urology
关键词
尿道狭窄
生长因子Β1
patients with urethral strictures
TGF -β1
