摘要
目的:探讨脂联素,胰岛素与胎儿生长发育的关系。方法:选取21例分娩生长受限胎儿(FGR组)、21例分娩巨大儿(巨大儿组)及21例分娩正常儿(对照组)的产妇,抽取3组产妇分娩后肘静脉血及其新生儿脐静脉血.分离血清。采用双抗体夹心酶联免疫吸附法和放射免疫法测定3组产妇血清及新生儿脐静脉血清中脂联素和胰岛素的水平。结果:FGR组产妇血清脂联素水平明显低于对照组及巨大儿组(P<0.01);FGR组新生儿脐血清脂联素水平明显低于对照组及巨大儿组(P<0.05);3组产妇血清中脂联素水平均明显低于新生儿脐血清中脂联素水平(P<0.01)。FGR组胎盘重量明显低于对照组及巨大儿组(P<0.01);3组产妇血清及新生儿脐血血清中胰岛素水平差异无显著性(P>0.05)。3组产妇血清脂联素水平与胰岛素水平无相关(P>0.05);3组新生儿脐血清脂联素水平与胰岛素水平呈明显负相关性(P<0.05);3组产妇血清脂联素水平与新生儿脂联素水平无相关(P>0.05);3组产妇血清胰岛素水平和新生儿脐血胰岛素水平无相关性(P>0.05)。3组新生儿脐血清脂联素水平与新生儿出生体重、胎盘重量、新生儿头围、身长、体重/身长比呈明显正相关关系(P<0.05);3组新生儿脐血清胰岛素水平、产妇血清脂联素水平、产妇血清胰岛素水平与新生儿出生体重、胎盘重量、头围、身长、体重/身长比均无相关性。结论:脐血中的脂联素、胰岛素在胎儿宫内生长和发育过程中可能起重要的调节作用,可作为评价胎儿生长发育及体内脂肪储备状态的临床指标之一。胎儿自身分泌的脂联素与胎儿生长关系密切。
Objective：To explore the effects of insulin and adiponectin on the fetal growth. Methods：Samples of maternal blood and matched umbilical cord blood were collected at time of delivery from 21 mothers and newborns with nomal birth weight（control group） ,21 pairs with fetal growth restriction （FGR group ） and 21 pairs with maerosomia （macrosomia group）. Serum insulin was measured by radiommunoassay （RIA） , serum adiponectin was measured by The enzyme-linked immunosorbent assay. Results： （1） The level of matermal serum adiponectin in FGR groups was significantly lower than that in macrosomia and control groups （P〈 0.01）. The level of cord blood adiponectin in FGR groups was significantly lower than that in macrosomia and control groups（P〈0.05）. In this three group the levels of maternal serum adiponectin were significantly lower than that of fetal levels（P〈0.01）. （2） The placental weight in the FGR groups was significantly lower than that in macrosomia and control groups（435.2±10.6g vs 538.6±11.0g vs 682.5±13.7g, P〈0.01）.（3） The level of matermal serum insulin among FGR,macrosornia and control groups had no significantly different（P〉0.05）. The level of cord blood insulin among FGR, macrosomia and control groups had no significantly different（P〉0.05） .（4） In the three group the levels of maternal serum adiponeetin and insulin had no positively correlated （r=-0.074, r =0.189, r =-0.054, P〉0.05） ; The level of cord blood adiponectin was negitively significantly correlated with insulin （r=-0.536, r =-0.462, r=-0.434, P〈0.05） ; The level of maternal serum adiponectin and the cord blood adiponectin had no positiyely correlated（r=0.214,P〉0.05）;In the three group the levels of maternal serum insulin and the cord blood insulin had no positively correlated（r=0.243 ,P〉0.05）. （5）The level of cord blood adiponectin was positively correlated with their birth weight, placental weight, head circumference and body length, birth weight/body length ratio（r=0.283, r=0.259,r=0.325 ,r=0.278 ,P〈0.05） ;The level of cord blood insulin and the maternal serum adiponection and insulin had no positively correlated with their birth weight, placental weight, head circumference and body length, birth weight/body length ratio （ P〉0.05 ）. Conclusions： Cord blood adiponectin and insulin may play an important role in fetus growth and development, they can be regarded as one of the clinical indexes to evaluate fetus growth and development and fat depot condition. The Cord blood adiponectin have correlated with the fetal growth.
出处
《现代妇产科进展》
CSCD
北大核心
2009年第10期772-776,共5页
Progress in Obstetrics and Gynecology
