摘要
目的探讨三种炎症因子超敏C反应蛋白(hsCRP)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-á)与糖尿病前期发生的相关性。方法94名35~70岁志愿者被纳入研究,其中61名糖尿病前期者和33名正常血糖者。对纳入研究者进行身高、体重、腰围、臀围、血压测量;计算BMI、腰臀比;行口服糖耐量试验(OGTT);检测血脂、尿酸、hsCRP、IL-6,TNF-á等。比较糖尿病前期组与正常血糖组hsCRP、IL-6、TNF-á及上述代谢指标水平的差异,并分析hsCRP、IL-6、TNF-á与其他代谢指标的相关性。结果糖尿病前期组hsCRP(2.17±0.39)mg/L、IL-6(3.11±0.66)pg/ml、TNF-α(3.10±0.37)pg/ml,均高于正常血糖组hsCRP(1.99±0.42)mg/L、IL-6(2.82±0.47)pg/ml、TNF-α(3.09±0.28)pg/ml,两组比较hsCRP、IL-6差异均具有统计学意义(P<0.05);相关分析显示hsCRP水平与体重、腰围、臀围、腰臀比、OGTT2h血糖、甘油三酯、尿酸呈正相关。逐步回归分析显示影响hsCRP(y1)水平的主要因素为腰臀比(a1)、甘油三酯(b1)、收缩压(c1)、舒张压(d1)、肿瘤坏死因子(e1)、OGTT2小时血糖(f1)。回归方程:y1=-5.428+3.507a1+0.068b1-0.009c1+0.009d1+0.211e1+0.033f1。在调整年龄、性别等影响因素后,hsCRP(OR=3.715,P<0.05)、IL-6(OR=2.647,P<0.05)与糖尿病前期的发生相关。结论糖尿病前期者hsCRP、IL-6水平高于正常血糖者。hsCRP、IL-6、TNF-á水平的升高可能是发生糖尿病前期的危险因素。
Objective To evaluate the correlation between prediabete and inflammatory factors such as high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor necrosis factor-á(TNF-α). Methods 94 volunteers( aged between 35 to 70 years) were enrolled in the research, including 61 prediabetes and 33 normal glucose. Anthropometric measurements such as body height,body weight,waist circumference, hip circumference and blood pressure were obtained;BMI, waist-to-hip ratio were calculated.Each subject underwent oral glucose tolerance test.Fasting glucose,OGTT 2 hours glucose,blood-fat,uric acid, high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-á were detected in them.The levels of inflammatory factors and other metabolic indicators were analyzed between the prediabetes and normal blood glucose. And the correlation between prediabete and inflammatory factors were evaluated.Results Prediabetes group had higher median levels of hsCRP( 2.17±0.39) mg/L, IL-6(3.11±0.66) pg/ml, TNF-α(3.10±0.37) pg/ml than those with normal blood glucose.There are statistically significant difference between prediabetes and normal glucose among hsCRP, IL-6(P〈0.05).Weight, waist circumference, hip circumference,OGTT 2 hours glucose,triglyceride,uric acid were positively correlated with hsCRP level.Stepwise analysis showed that the main factors of hsCRP (y1) level were waist-to-hip ratio(a1),triglyceride (b1),DBP(c1), SBP(d1),TNF-(áe1).The equation was y1=-5.428+3.507a1+0.068b1-0.009c1+0.009d1+0.211e1+0.033f1. There was a positively correlation between hsCRP leve(OR=3.715, P〈0.05) and IL-6 level( OR=2. 647, P〈0.05)and the prediabetes after adjusting the influences of age and gender.Conclusions The levels of hsCRP,IL-6 in prediabetes were higher than those with normal blood glucose and hsCRP, IL-6, TNF-α may be the risk factors of prediabetes.
出处
《国际医药卫生导报》
2009年第22期1-4,共4页
International Medicine and Health Guidance News
基金
2009年广东省自然科学基金重点项目(9251008901000030)
863计划子课题(2006AA02A409)
番禺区科技计划项目(2007-Z-72-1)