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培本通幽汤对便秘小鼠抗衰老作用的实验研究

Study on anti-aging effect of Fostering root and passing barrier Formula on mice with constipation
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摘要 目的探讨培本通幽汤对便秘小鼠抗衰老的作用。方法将60只昆明种小鼠随机分为6组,雌雄各半,采用复方苯乙哌啶制作小鼠便秘模型,分别给予相应药物,第5天处死小鼠,检测血清和脑中一氧化氮(NO)含量,取小鼠胸腺测定胸腺厚度以及皮质淋巴细胞数量,以了解便秘指标的改善情况。结果培本通幽汤组小鼠血清和脑中NO含量、胸腺厚度、皮质淋巴细胞数量与正常对照组比较无显著性差异(P均>0.05),高、中剂量组与模型对照组比较有显著性差异(P均<0.05),其作用与剂量呈正相关。结论培本通幽汤通过改善便秘小鼠血液及脑组织中NO含量,提高机体免疫力及抗氧化能力,从而延缓衰老。 Objective It is to approach the anti-aging effect of Fostering root and passing barrier Formula (FRPBF) on the mice with constipation. Methods 60 mice were divided into six groups, female and male equaled parts, the constipation mice models were induced by compound Diphenoxylate, the corresponding drug were fed respectively in each group, Then the mice were executed after 5 days. The contents of NO in the blood serum and the brain were detected. The thymus thickness and the lymph cell quantity in the cortex were measured, and the improve status was observed. Results There was no difference in the NO contents in the blood serum and the brain, thymus thickness and the lymph cell quantity between the FRPBF groups and the normal group (P 〉0.05). But compared with the model group, the difference was significant (P 〈 0.05). The effect of FRPBF was depended on the dose. Conclusion FRPBF can improve the body immunity and anti-oxidation effect, and delay the aging by the means of changing the NO contents in the blood serum and the brain.
作者 刘畅
出处 《现代中西医结合杂志》 CAS 2009年第33期4064-4065,4070,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词 培本通幽汤 便秘 抗衰老 小鼠 Fostering root and passing barrier Formula constipation anti-aging mouse
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