摘要西尼罗病毒病是由西尼罗病毒(West Nile Virus,WNV)感染所致的人畜共患虫媒传染病.主要临床表现为发热、头痛、肌痛、皮疹,同时伴淋巴结肿大。部分患者有恶心、呕吐、腹泻、腹痛等胃肠道症状。少数患者可出现无菌性脑膜炎或脑膜脑炎,表现为头痛、高热、眩晕、严重肌肉乏力、震颤、麻痹、惊厥、意识障碍、昏迷等。
3Paricia A, Devine MD. West Nile virus infection. Infect Dis Update, 2003, 10(4): 191-195.
4CDC. West Nile virus activity. United States, MMWR Morb Mortal Wkly Rep, 2003, 52(47): 1160.
5CDC. West Nile virus activity. United States, MMWR Morb Mortal Wkly Rep, 2004, 53(42): 996.
6Klein D. Quantification using real-time PCR: applications and limitations. Trends Mol Med, 2002, 8(6): 257-260.
7Niesters HGM. Quantification of viral load using real-time amplification techniques. Methods, 2001, 25: 419-429.
8Lanciotti RS, Kerst AJ, Nasci RS, et al. Rapid detection of West Nile virus from human clinical specimens, field-collected mosquitoes, and avian samples by a TaqMan reverse transcriptase-PCR assay. J Clin Microbiol, 2000, 38(11): 4066-4071.
9Briese T, Glass WG, Lipkin WL. Detection of West Nile virus sequences in cerebrospinal fluid. Lancet, 2000, 355: 1614-1615.
10Shi PY, Kauffman EB, Ren P, et al. High-throughput detection of West Nile virus RNA. J Clin Microbiol, 2001, 39(4): 1264-1271.