摘要
目的:研究莫昔沙星对苯妥英钠药动学的影响。方法:10只家兔耳缘静脉推注苯妥英钠(10mg·kg-1),给药后10、30、60、120、240、360、480min时采血样建立苯妥英钠单用组;自最后一次采血样后48h喂服莫昔沙星(10mg·kg-1)连续5d,第6天给药2h后静脉注射苯妥英钠(10mg·kg-1),不同时间采血样建立苯妥英钠与莫昔沙星合用组;以紫外分光光度法测定各组血样中苯妥英钠的血药浓度,以3p97药动学软件拟合药动学参数。结果:与单用组比较,合用组苯妥英钠血药浓度下降;2组AUC分别为(5836.22±489.13)、(4329.21±344.67)mg·min·L-1(P<0.05),t1/2β分别为(196.11±22.68)、(158.21±28.76)min(P<0.01),消除速度常数和清除率分别增加1.38、1.32倍(P<0.01),Vd无显著性差异(P>0.05)。结论:与莫昔沙星合用后苯妥英钠体内代谢速度加快。
OBJECTIVE： To study the effect of moxifloxacin on pharmacokinetics of phenytoin sodium in rabbits. METHODS： A total of 10 rabbits were injected with phenytoin sodium （10mg·kg-1） via the vein in ear edge, with serum samples taken at 10, 30, 60, 120, 240, 360, and 480 rain, respectively for establishing phenytoin sodium alone group. 48 h after the last sampling, the rabbits were given oral moxifloxaein （10 mg·kg-1） for 5 consecutive days; on day 6, the rabbits were injected with phenytoin sodium （10mg·kg-1） at 2 h after oral administration of moxifloxacin, then serum samples were taken at different time points for establishing combination group of phenytoin sodium and moxifloxacin. The serum concen- trations of phenytoin sodium at different time points were determined by UV - spectrophotometry and the pharmacokinetic parameters were computed with 3p97 program. RESULTS： The plasma concentration of phenytoin sodium reduced in the combination group compared with alone group. The AUC in the two groups was （5 836.22 ± 489.13） vs. （4 329.21± 344.67） mg ·min · L -1 （p 〈 0.05） ; the t 1/2 was （196.11± 22.68） vs. （ 158.21 ± 28.76） min （P 〈 0.01）, the elimination rate constant and clearance rate increased by 1.38 and 1.32 times （P〈0.01）, respectively; however, no significant differences were noted with regard to Vd （P 〉 0.05） . CONCLUSION： The elimination of phenytoin sodium was significantly accelerated by combi- nation with moxifloxacin.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第34期2665-2666,共2页
China Pharmacy
关键词
莫昔沙星
苯妥英钠
紫外分光光度法
药动学
Moxifloxacin
Phenytoin sodium
UV-spectrophotometry
Pharmacokinetics
