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Kiss-1蛋白在鼻咽癌组织中的表达与意义 被引量：3

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摘要 目的:本实验通过检测Kiss-1蛋白在鼻咽癌组织中的表达以探讨其临床意义。方法:收集2006年1月1日至2007年10月30日蚌埠医学院第一附属医院病理科鼻咽癌存档蜡块67例及非肿瘤性鼻咽部组织存档蜡块30例。应用免疫组织化学方法(IHC)检测Kiss-1蛋白在肿瘤细胞和正常鼻咽黏膜细胞中的表达情况。结果:鼻咽癌组和正常鼻咽部组织中Kiss-1蛋白阳性率分别为59.7%(40/67)和83.3%(25/30),二者差异有统计学意义(P<0.05)。Kiss-1蛋白表达的高低与淋巴结转移(N分期)显著相关(P<0.05)。结论:Kiss-1在鼻咽癌组织中的表达率显著低于非肿瘤性鼻咽上皮组织;Kiss-1的表达率降低与鼻咽癌的淋巴结转移有关。
作者 汪庚明 江浩 承泽农 项平 张磊
机构地区 安徽省蚌埠医学院第一附属医院肿瘤放疗科 蚌埠医学院病理教研室 安徽省蚌埠医学院第一附属医院中心实验室
出处 《实用医学杂志》 CAS 北大核心 2009年第23期3974-3976,共3页 The Journal of Practical Medicine
基金 安徽省高校省级自然科学研究项目(编号:KJ20078199)
关键词 鼻咽肿瘤 KISS-1基因 肿瘤转移
分类号 R739.63 [医药卫生—肿瘤]
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参考文献21

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二级参考文献43

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二级引证文献7

实用医学杂志
2009年 第23期

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