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血压管理对高血压脑出血患者血肿周围水肿的影响 被引量:6

Effect of blood pressure management on perihematomal edema in palients with hype^ensive inWacerebral hemordmge
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摘要 目的探讨高血压脑出血急性期血压管理对血肿周围水肿的影响。方法采用回顾性研究方法,对2005年6月-2007年12月期间高血压脑出血住院患者的年龄、天数、降压药、脱水药和血压等因素进行logistic回归分析。结果多因素分析发现,氨氯地平(OR=0.208,95%CI 0.063~0.684)和血管紧张素转换酶抑制药(OR=0.280,95%CI 0.085~0.920)均为血肿周围水肿的保护因素;病程天数10~20d(OR=7.413,95%CI 1.362~40.360)、舒张压控制不良(OR=6.449,95%CI 1.01 1—41.145)均为血肿周围水肿的危险因素。结论服用氨氯地平和血管紧张素转换酶抑制药能降低脑出血血肿周围水肿的风险,而舒张压控制不良和病程10~20d为血肿周围水肿的危险因素。 Objective To investigate the effect of blood pressure management on perihematomal edema in patients with acute hypertensive intracerebral hemorrhage. Methods The retrospective research method was used to conduct logistic regression analysis for the factors of age, number of days, antihypertensive drugs, dehydrating agents, and blood pressure in inpatients with hypertensive intracerebral hemorrhage from June 2005 to December 2007. Results Multivariate analysis found that both amlodipine (OR = 0.208, 95% CI 0. 063- 0. 684) and angiotensin-converting enzyme inhibitor (ACEI) (OR = 0.280, 95% CI 0. 085- 0. 920) were the protective factors for perihematomal edema; both the course of 10 to 20 days (OR=7. 413,95% CI 1. 362-40. 360) and poorly controlled diastolic blood pressure (OR = 6. 449, 95% CI 1.011-41. 145) were the risk factors for perihematomal edema. Conclusions Amlodipine and ACEI may lower the risk of perihematomal edema in intracerebral hemorrhage, while the poorly controlled diastolic blood pressure and the course of 10 to 20 days are the risk factors for perihematomal edema.
出处 《国际脑血管病杂志》 北大核心 2009年第10期742-746,共5页 International Journal of Cerebrovascular Diseases
基金 福建医科大学教授学术发展基金(JS08014)
关键词 脑出血 脑水肿 高血压 钙通道阻滞药 血管紧张素转换酶抑制药 cerebral hemorrhage brain edema hypertension calcium channel blockers angiotensin-converting enzyme inhibitors
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  • 1卫生部疾病预防控制局,中华医学会神经病学分会.中国脑血管病防治指南.北京:人民卫生出版社,2007:37.
  • 2Qureshi AI, Ezzeddine MA, Nasar A, et al. Prevalence of elevated blood pressure in 563,704 adult patients with stroke presenting to the ED in the United States. Am J Emerg Med, 2007, 25: 32-38.
  • 3Anderson CS, Huang Y, Wang JG, et al; INTERACT Investigators. Intensive blood pressure reduction in acute cerebral haemorrhage trial (INIERACT): a randomised pilot trial. Lancet Neurol, 2008, 7: 391-399.
  • 4各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33029
  • 5Tada A, Hisada K, Suzuki T, et al. Measurement volume of intracranial hematoma by computed tomography (author's transl). No Shinkei Geka, 1981, 9:251-256.
  • 6吴钢.关于高血压卒中急性期的血压调控机制与血压管理的思考[J].中国卒中杂志,2007,2(9):780-783. 被引量:13
  • 7Lee KR, Kawai N, Kim S, et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model. J Neurosurg, 1997, 86: 272-278.
  • 8Gaab MR, Hollerhage HG, Walter GF, et al. Brain edema, autoregulation, and calcium antagonism. An experimental study with nimodipine. Adv Neurol, 1990, 52: 391-400.
  • 9Xi G, Keep RF, Hoff JT. Pathophysiology of brain edema formation. Neurosurg Clin N Am, 2002, 13: 371-383.
  • 10王新德.神经系统血管性疾病[M].北京:人民军医出版社,2001.31-67.

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