摘要
目的观察美罗培南联合鞘内注射头孢他啶治疗中枢神经系统(CNS)革兰阴性杆菌感染的临床疗效。方法76例CNS革兰阴性杆菌感染患者按静脉应用不同抗生素分为2组:A组40例和B组36例。A组采用美罗培南1.0 g+NS 250 mL静脉滴注,3次/d;B组采用头孢他啶2.0 g+NS 250 mL静脉滴注,2次/d。同时2组均采用头孢他啶100 mg+NS 10 mL鞘内注射,1次/d。2组疗程均为2周。观察2组鞘内注射率及预后情况。结果A、B2组鞘内注射率均为100%,2组比较差异无统计学意义(P>0.05)。A组治愈率为92.5%,B组为47.2%,2组比较差异有统计学意义(均P<0.05)。结论静脉应用美罗培南联合鞘内注射头孢他啶可显著提高CNS革兰阴性杆菌感染治愈率。
Objective To explore the therapeutic effect of meropenem combined with intrathecal injection of ceftazidime on central nervous system（CNS） infections with gram negative bacilli. Methods 76 cases of CNS infection with gram negative bacilli were divided into two groups： group A（n=40） and group B（n=36）. For group A, the patients were treated with intravenous administration of 1.0 g meropenem in 250 mL NS,3 times/d. For group B,the patients were treated with intravenous administration of 2.0 g ceftazidimein in 250 mL NS,2 times/d. Meanwhile, the two groups received intrathecal injection of 100 mg ceftazidime in NS 10 mL, 1 times/d. The treatment lasted for 2 weeks,followed by observation of intrathecal injection rate and prognosis. Results The respective intrathecal injection rate of both groups was 100% ,and there was no significant statistical difference between the two groups（P〉0.05）. The healing rate of both group was respectively 92.5% in group A and 47.2% in group B,which showed significant difference （P〈0.05）. Conclusion Intravenous administration of meropenem combined with intrathecal injection of ceftazidime can significantly increase the healing rate of CNS infection with gram negatire bacilli.
出处
《江西医学院学报》
2009年第8期60-62,共3页
Acta Academiae Medicinae Jiangxi
关键词
中枢神经系统感染
革兰阴性杆菌
鞘内注射
美罗培南
头孢他啶
central nervous system infection
gram negative bacilli
intrathecai injection
meropenem
ceftazidime
