摘要
目的:探讨木樨草素对高血脂大鼠血清抗氧化功能的作用及其可能机制。方法:建立高血脂大鼠模型,观察给药后血脂水平和血清T-AOC、SOD、CAT和MDA变化。结果:各剂量药物组血清中TC、TG和MDA水平显著低于模型对照组(P<0.05),HDL-C水平显著高于模型对照组(P<0.05),T-AOC、SOD、CAT活性显著高于模型对照组(P<0.05)。结论:木樨草素可提高高血脂大鼠血清抗氧化酶活性,降低脂质过氧化程度。
High, medium and low doses of luteolin were administered to high fat diet-induced hyperlipidemic rat model established in adult Sprague-Dawley rats for investigating its effects on the levels of blood lipid and antioxidant indexes in hyperlipidemia rats, including MDA content, T-AOC, and SOD and CAT activities. Results showed that all three dose groups exhibited significantly lower levels of TC, TG and MDA and higher levels of HDL-C, T-AOC, SOD and CAT when compared with model control group （P 〈 0.05）. In conclusion, luteolin＇might contribute to improve the serum antioxidant capability and reduce the lipid peroxidative damage in hyperlipidemic rats.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2009年第21期348-350,共3页
Food Science
关键词
木樨草素
高血脂
抗氧化能力
luteolin
hyperlipidemia
antioxidant capability
