摘要
多发性硬化（MS）是一种以中枢神经系统白质神经变性为特征的自身免疫性疾病，其确切的病因发病机制尚不清楚。目前认为是在易感基因的基础上，受环境因素的触发由CD4^＋T细胞介导的中枢神经系统的自身免疫性疾病，但其他免疫细胞（包括B细胞、CD8^＋T细胞等）也能通过诱导或调控MS患者中枢神经系统内的免疫应答过程而可能参与MS的发病。以往认为Th1／Th2型反应失衡是其关键致病因素，近年来随着对其研究的深入，提出许多新的观点，为多发性硬化的免疫机制及治疗策略研究提供了新方向。
Multiple sclerosis （MS） is a kind of autoimmune diseases. It is characterized by neural degeneration in white matter of central nervous system. Its etiological factor and pathogenesis are unclear. It is believed that the main pathogenesis factor of MS is the unbalance of Th1/Th2 immunoreaction, while other immunocytes, such as CD8^＋ T cells, B lymphocytes, and innate immune factors also take part in its pathopoiesis. Reacently some novel ideas are proposed through intensive reseaches. Particular interest is currently focused on a distinct lineage of T cells that specialize in IL-17 production （Th17） which exerts a pathogenesis role in EAE. It has been proposed that the activity of regulatory CD4 ＋ CD25^＋ Foxp3^＋ T cells ameliorates the clinical symptoms of EAE and restrain the progress of the disease in several animal models. It provides new insight for the study of the immune mechanism and the developonent treatment strategies of MS.
出处
《国际免疫学杂志》
CAS
北大核心
2009年第6期468-471,共4页
International Journal of Immunology
关键词
多发性硬化
感染损伤
T细胞
B细胞
固有免疫
Multiple sclerosis
Infection and damage
T ceils
B cells
Innate immunity
