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尿苷二磷酸葡萄糖醛酸转移酶1A7基因多态性与膀胱癌易感性的关系 被引量：1

Association between genetic polymorphism of UGT1A7 and susceptibility of bladder cancer
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摘要 目的探讨尿苷二磷酸葡萄糖醛酸转移酶1A7（UGTlA7）基因多态性与膀胱癌易感性的关系。方法以病例对照研究方法，应用半巢式PCR（SN—PCR）和等位基因特异性PCR（AS—PCR）分别检测208例膀胱癌患者和205例非肿瘤患者的UGTlA7基因多态性，对各基因型和等位基因单独或联合吸烟行为进行统计学分析。结果膀胱癌组变异纯合基因型[＊x／＊X（X=＊2，＊3，＊4）]的频率（20．7％）高于对照组（12．2％），差异有统计学意义[P〈0．05，OR=2．16（1．18～3．96）]。膀胱癌组携带变异等位基因’3的频率（27．9％）高于对照组（20．5％），差异有统计学意义[P=0．009，OR=1．56（95％CI：1．12—2．18）]。吸烟人群中，变异杂合基因型[＊x／＊X（X=＊2，＊3，＊4）]或变异纯合基因型者与野生型者相比，膀胱癌组和对照组间差异有统计学意义，oR（95％a）值分别为2．16（1．07～4．36）、2．64（1．02～6．80）。UGT1A7基因多态性与膀胱癌病理分级和临床分期均无相关性（均P〉0．05）。结论UGT1A7基因多态性与膀胱癌易感性有关，该基因多态性与吸烟行为在膀胱癌的发生中存在交互作用。 Objective To investigate the association between genetic polymorphism of UGT1 A7 and susceptibility of bladder cancer. Methods Based upon a case-control study, UGT1A7 polymorphisms were determined by the semi-nested polymerase chain reaction （SN-PCR） and allele-specific polymerase chain reaction （AS-PCR） in 208 cases with bladder cancer and 205 non-tumor controls. Risks were evaluated by unconditional logistic regression analysis. Results The frequency of variant homozygous genotype in cases （20. 7% ） was higher than that in controls （12. 2% ） and the difference was statistically significant [P 〈 0. 05, OR =2. 16 （1.18 -3.96）]. The frequency of variant allele ＊3 in cases was higher than that in controls （27. 9%, 20. 5% respectively） and the difference was statistically significant [ P = 0. 009, OR = 1.56 （95% CI： 1.12 -2. 18）]. The smokers with variant homozygous and heterozygous genotypes showed an increased risk of bladder cancer compared with those with wild genotype [ 2. 16 （95% CI： 1.07 -4. 36）, 2. 64 （95% CI： 1.02 - 6. 80） respectively ]. There was no association between the UGT1 A7 polymorphisms and the pathological grade and clinical stage of bladder cancer （ both P 〉 0. 05 ）. Conclusion The genetic polymorphisms of UGT1A7 are associated with the susceptibility of bladder cancer and have interactions with smoking in bladder carcinogenesis.
作者 刘建 杨小明 刘刚 常连胜 张莉蓉 宋东奎
机构地区 郑州大学第一附属医院泌尿外科郑州大学肿瘤分子外科研究所 郑州大学基础医学院药理教研室
出处 《中华医学杂志》 CAS CSCD 北大核心 2009年第44期3122-3125,共4页 National Medical Journal of China
基金 基金项目：河南省科技厅科技攻关项目（072102310106）
关键词 膀胱肿瘤 多态性 单核苷酸 吸烟 UGT1A7 Urinary bladder neoplasms Polymorphism, single nucleotide Smoking UGT1A7
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献13

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二级参考文献16

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共引文献11

同被引文献10

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中华医学杂志
2009年 第44期

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