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脑瘤手术时异丙酚的脑保护作用 被引量:11

Cerebral protective effect of propofol during brain tumor resection
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摘要 目的:探讨脑瘤手术期间异丙酚在体内的抗氧化特性及脑保护作用。方法:择期行脑瘤手术患者20例。随机分为观察组(异丙酚组,A组,n=10)和对照组(异氟醚组,B组,n=10)。以电子自旋共振方法测定血浆OFR及用化学方法测定LPO含量。结果:两组手术前OFR、LPO显著高于正常值。开颅手术2小时后两组OFR、LPO较术前显著性升高(P<0.05),开颅手术4小时后观察OFR、LPO较术前及手术2小时后显著性降低(P<0.01),而对照组则较手术2小时后显著性升高(P<0.01)。结论:脑瘤患者术前存在OFR代谢紊乱,开颅手术可加重脑的再灌注损伤。临床麻醉剂量的异丙酚可有效地清除OFR,有显著的脑保护作用。 Objective: To study the antioxide properties of propofol in vivo and its cerebral protective effect during brian tumor resection. Method: Twenty patients scheduled for undergoing brain tumor resection,were randomized to receive propofol (group A, n=10) and isoflurane (group B, n=10) as control. Electron spin resonance spectroscopy method was used to measure plasma oxygen free radicals (OFR) and thiobarbitaI method to measure the plasma lipid peroxide (LPO) level. Result:The OFR and LPO levels were significantly higher in all patients than normal values before operation(P<0.05). In both groups the OFR and LPO levels were significantly increased after two hours of neurosurgery compared with those before operation(P<0.01). In group A,the two values reduced markadly four hours following neurosurgery compared with those before operation and two hours following neurosurgery (P<0.01), but in group B were more than those two hours following neurosurgery (P<0.01), with significant differences between both groups (P<0.01). Conclusion:There is OFR metabolism disorder in patients with brain tumor before operation. Surgical procedures on the brain may induce secondary cerebral ischemia causing neurologic injury. Therapeutic dose of propofol may play a role in brain protection and act as an OFR scavenger in vivo. Intravenous infusion of propofol during neurosurgery can abate the secondary cerebral injury.
作者 梁敏 白令君
出处 《中华麻醉学杂志》 CAS CSCD 北大核心 1998年第11期668-670,共3页 Chinese Journal of Anesthesiology
关键词 脑肿瘤 氧自由基 过氧化脂质 二异丙酚 外科手术 Brain Neoplasms Oxygen free radical Lipid peroxides Propofol
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参考文献6

  • 1张良成,中华麻醉学杂志,1998年,18卷,164页
  • 2高国栋,中华神经外科杂志,1998年,4期,155页
  • 3马秋兰,国外医学.脑血管疾病分册,1996年,4卷,134页
  • 4梁敏,天津医药,1996年,24卷,451页
  • 5贾健民,国外医学.神经病学神经外科学分册,1995年,22卷,205页
  • 6费舟,中华神经外科杂志,1982年,8卷,35页

同被引文献54

  • 1杨军良,陈伯銮.新的静脉麻醉药:双异丙酚[J].国际麻醉学与复苏杂志,1992,26(3):129-132. 被引量:59
  • 2刘微.异丙酚在ICU的应用[J].国外医学(麻醉学与复苏分册),1996,17(3):163-164. 被引量:11
  • 3盛卓人.控制性降压的前景[J].中华麻醉学杂志,1996,16(9):435-435. 被引量:31
  • 4王祥瑞,孙大金,杭燕南,许灿然,金正均.异丙酚的血药浓度与临床效应的关系[J].中华麻醉学杂志,1996,16(7):292-294. 被引量:67
  • 5史玉泉.实用神经病学(第2版)[M].上海:上海科学技术出版社,1994.736.
  • 6易声禹.努力提高颅脑损伤救治整体水平[J].中华神经外科杂志,1998,(1):1-1.
  • 7周君富 陈建新.自由基生命科学发展[M].北京:原子能出版社,1994.83-85.
  • 8叶平安 朱银南.实用麻醉药理学(第一版)陕西[M].陕西:陕西科学技术出版社,1995.389-395.
  • 9张洁 梁伟民 等.异丙酚对颅内压的影响[J].麻醉与重症监测治疗,1995,1:37-37.
  • 10曹作为.重型颅脑损伤287例分析[J].中华外科杂志,1981,19:746-749.

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