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穹隆—海马伞切断与卵巢切除对AD大鼠脑组织BDNF表达的影响

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摘要 目的进一步探讨脑源性神经营养因子(BDNF)在阿尔茨海默病(AD)发生、发展中的作用。方法将20只大鼠随机分为四组各5只,双侧卵巢切除组(OVX组)行双侧卵巢切除,双侧穹隆—海马伞切断组(FF组)行双侧穹隆—海马伞切断,双侧卵巢切除加双侧穹隆—海马伞切断组(OF组)分别行上述手术,对照组不行任何手术。应用免疫细胞组织化学技术观察各组海马CA1区、皮质区、杏仁复合体区、基底前脑Meynert核区BDNF蛋白表达变化。结果双侧卵巢切除和双侧穹隆—海马伞切断与否对不同部位脑组织BDNF阳性细胞的表达存在显著的交互效应(P<0.01)。结论BDNF数量下降与AD的发生、发展密切相关。
作者 申永帆 于玲
机构地区 日照市东港区人民医院
出处 《山东医药》 CAS 北大核心 2009年第43期41-42,共2页 Shandong Medical Journal
关键词 阿尔茨海默病 脑源性神经营养因子 穹隆-海马伞 卵巢 鼠
分类号 R742 [医药卫生—神经病学与精神病学]
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山东医药
2009年 第43期

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